About: A cascade reaction network mimicking the basic functional steps of acquired immune response

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A cascade reaction network mimicking the basic functional steps of acquired immune response
Creator	Zhang, Tao Chen, Tao Tan, Weihong Liang, Hao Han, Da Wu, Cuichen Qiu, Liping Wan, Shuo You, Mingxu Zheng, Zheng
Source	PMC
abstract	Biological systems use complex ‘information processing cores’ composed of molecular networks to coordinate their external environment and internal states. An example of this is the acquired, or adaptive, immune system (AIS), which is composed of both humoral and cell-mediated components. Here we report the step-by-step construction of a prototype mimic of the AIS which we call Adaptive Immune Response Simulator (AIRS). DNA and enzymes are used as simple artificial analogues of the components of the AIS to create a system which responds to specific molecular stimuli in vitro. We show that this network of reactions can function in a manner which is superficially similar to the most basic responses of the vertebrate acquired immune system, including reaction sequences that mimic both humoral and cellular responses. As such, AIRS provides guidelines for the design and engineering of artificial reaction networks and molecular devices.
has issue date	2015-08-17(xsd:dateTime)
bibo:doi	10.1038/nchem.2325
bibo:pmid	26391084
has license	no-cc
sha1sum (hex)	c25538e27e526befc45cca82114de9d628da3590
schema:url	https://doi.org/10.1038/nchem.2325
resource representing a document's title	A cascade reaction network mimicking the basic functional steps of acquired immune response
has PubMed Central identifier	PMC4580978
has PubMed identifier	26391084
schema:publication	Nat Chem
resource representing a document's body	covid:c25538e27e526befc45cca82114de9d628da3590#body_text
is schema:about of	named entity 'environment' named entity 'responses' named entity 'cores' named entity 'SPECIFIC' named entity 'REACTION' named entity 'VERTEBRATE' named entity 'PROCESSING' named entity 'HERE' named entity 'PROTOTYPE' named entity 'CORES' named entity 'SIMILAR' named entity 'USED' named entity 'acquired' named entity 'prototype' named entity 'enzymes' named entity 'Here' named entity 'molecular devices' named entity 'vertebrate' named entity 'external environment' named entity 'network of reactions' named entity 'adaptive immune response' named entity 'cascade reaction' named entity 'coordinate' named entity 'active domains' named entity 'fluorescence' named entity 'Tris base' named entity 'immune tolerance' named entity 'fluorescently' named entity 'SARS' named entity 'adaptive immune' named entity 'genome' named entity 'quencher' named entity 'enzyme' named entity 'cellular components' named entity 'pathogen' named entity 'duplex DNA' named entity 'gel electrophoresis' named entity 'fluorescence' named entity 'host immunity' named entity 'B-cell' named entity 'genome' named entity 'chemical reactions' named entity 'DNA polymerase' named entity 'foreign body' named entity 'memory effect' named entity 'Gram-positive' named entity 'restriction enzyme' named entity 'T-cell' named entity 'SspI' named entity 'fluorescein isothiocyanate' named entity 'Phi29 polymerase' named entity 'hybridization' named entity 'entropy' named entity 'single-stranded' named entity 'chemical reactions' named entity 'infectivity' named entity 'mimicry' named entity 'hybridization' named entity 'signalling pathways' named entity 'antigen' named entity 'humoral' named entity 'SspI' named entity 'hybridization' named entity 'cellular immune response' named entity 'entropy' named entity 'fluorescence' named entity 'cell-cell communication' named entity 'pathogen' named entity 'high molecular weight' named entity 'SARS' named entity 'pathogen' named entity 'Fluorescence'

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