About: Octahydroquinoxalin-2(1H)-One-Based Aminophosphonic Acids and Their Derivatives

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About: Octahydroquinoxalin-2(1H)-One-Based Aminophosphonic Acids and Their Derivatives—Biological Activity towards Cancer Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Octahydroquinoxalin-2(1H)-One-Based Aminophosphonic Acids and Their Derivatives—Biological Activity towards Cancer Cells
Creator	Iwanejko, Jakub Maciejewska, Magdalena Turlej, Eliza Wietrzyk, Joanna Wojaczyńska, Elżbieta
Source	Medline; PMC
abstract	In the search for new antitumor agents, aminophosphonic acids and their derivatives based on octahydroquinoxalin-2(1H)-one scaffold were obtained and their cytotoxic properties and a mechanism of action were evaluated. Phosphonic acid and phosphonate moieties increased the antiproliferative activity in comparison to phenolic Mannich bases previously reported. Most of the obtained compounds revealed a strong antiproliferative effect against leukemia cell line (MV-4-11) with simultaneous low cytotoxicity against normal cell line (mouse fibroblasts-BALB/3T3). The most active compound was diphenyl-[(1R,6R)-3-oxo-2,5-diazabicyclo[4.4.0]dec-4-yl]phosphonate. Preliminary evaluation of the mechanism of action showed the proapoptotic effect associated with caspase 3/7 induction.
has issue date	2020-05-22(xsd:dateTime)
bibo:doi	10.3390/ma13102393
bibo:pmid	32455965
has license	cc-by
sha1sum (hex)	c04d5bb86709136b1f1928eb29ede53b27962dde
schema:url	https://doi.org/10.3390/ma13102393
resource representing a document's title	Octahydroquinoxalin-2(1H)-One-Based Aminophosphonic Acids and Their Derivatives—Biological Activity towards Cancer Cells
has PubMed Central identifier	PMC7287629
has PubMed identifier	32455965
schema:publication	Materials (Basel)
resource representing a document's body	covid:c04d5bb86709136b1f1928eb29ede53b27962dde#body_text
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