About: Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report

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About: Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report
Creator	Krishna, Sanjeev Zaki, Sherif Wong, Kum Adem, Patricia Chandran, Patricia Cox-Singh, Janet Divis, Paul Hiu, Jessie Lucas, Sebastian Singh, Balbir Zulkarnaen, Mohammad
Source	PMC
abstract	BACKGROUND: Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here. CASE PRESENTATION: A formerly healthy 40 year-old male became symptomatic 10 days after spending time in the jungle of North Borneo. Four days later, he presented to hospital in a state of collapse and died within two hours. He was hyponatraemic and had elevated blood urea, potassium, lactate dehydrogenase and amino transferase values; he was also thrombocytopenic and eosinophilic. Dengue haemorrhagic shock was suspected and a post-mortem examination performed. Investigations for dengue virus were negative. Blood for malaria parasites indicated hyperparasitaemia and single species P. knowlesi infection was confirmed by nested-PCR. Macroscopic pathology of the brain and endocardium showed multiple petechial haemorrhages, the liver and spleen were enlarged and lungs had features consistent with ARDS. Microscopic pathology showed sequestration of pigmented parasitized red blood cells in the vessels of the cerebrum, cerebellum, heart and kidney without evidence of chronic inflammatory reaction in the brain or any other organ examined. Brain sections were negative for intracellular adhesion molecule-1. The spleen and liver had abundant pigment containing macrophages and parasitized red blood cells. The kidney had evidence of acute tubular necrosis and endothelial cells in heart sections were prominent. CONCLUSIONS: The overall picture in this case was one of systemic malaria infection that fit the WHO classification for severe malaria. Post-mortem findings in this case were unexpectedly similar to those that define fatal falciparum malaria, including cerebral pathology. There were important differences including the absence of coma despite petechial haemorrhages and parasite sequestration in the brain. These results suggest that further study of knowlesi malaria will aid the interpretation of, often conflicting, information on malaria pathophysiology in humans.
has issue date	2010-01-11(xsd:dateTime)
bibo:doi	10.1186/1475-2875-9-10
bibo:pmid	20064229
has license	cc-by
sha1sum (hex)	bf1d95ada5ce959db1a171eba72b349366a6748b
schema:url	https://doi.org/10.1186/1475-2875-9-10
resource representing a document's title	Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report
has PubMed Central identifier	PMC2818646
has PubMed identifier	20064229
schema:publication	Malar J
resource representing a document's body	covid:bf1d95ada5ce959db1a171eba72b349366a6748b#body_text
is schema:about of	named entity 'post-mortem' named entity 'TIME' covid:arg/bf1d95ada5ce959db1a171eba72b349366a6748b named entity 'malaria' named entity 'post-mortem' named entity 'Zoonotic' named entity 'case report' named entity 'post-mortem' named entity 'Severe malaria' named entity 'infection' named entity 'blood film' named entity 'parasitized' named entity 'pigment' named entity 'renal cortex' named entity 'Post-mortem' named entity 'endothelial cells' named entity 'falciparum malaria' named entity 'leucocytes' named entity 'malaria' named entity 'pigment' named entity 'falciparum malaria' named entity 'Endothelial cells' named entity 'subendocardial' named entity 'zoonotic' named entity 'liver' named entity 'PRBC' named entity 'orthologues' named entity '3, 4' named entity 'infection' named entity 'renal impairment' named entity 'severe malaria' named entity 'vertebrate' named entity 'outer surface' named entity 'P. knowlesi' named entity 'splenic' named entity 'malaria' named entity 'malaria parasites' named entity 'Haematoxylin' named entity 'Immunohistochemistry' named entity 'fatal disease' named entity 'endothelial cell' named entity 'ICAM-1' named entity 'petechial haemorrhages' named entity 'adhesion' named entity 'parenchymal' named entity 'surface antigens' named entity 'red cell' named entity 'P. falciparum' named entity '3, 4' named entity 'P. knowlesi' named entity 'dengue' named entity 'parasitism' named entity 'parasites' named entity 'PRBC' named entity 'P. falciparum' named entity 'P. falciparum' named entity 'liver' named entity 'petechial haemorrhages' named entity 'ICAM-1' named entity 'lung' named entity 'inflammation' named entity 'transferase' named entity 'macrophages' named entity 'cerebellar' named entity 'organ' named entity 'haemozoin' named entity 'post-mortem' named entity 'spleen' named entity 'DIC' named entity 'glomerular capillaries' named entity 'left ventricular'

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