About: The VNTR Polymorphism of the DC-SIGNR Gene and Susceptibility to HIV-1 Infection: A Meta-Analysis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The VNTR Polymorphism of the DC-SIGNR Gene and Susceptibility to HIV-1 Infection: A Meta-Analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The VNTR Polymorphism of the DC-SIGNR Gene and Susceptibility to HIV-1 Infection: A Meta-Analysis
Creator	Li, Hui Yu, Xiao-Min Hong, Ze-Hui Tang, Nelson Leung-Sang Wang, Jia-Xin
Source	PMC
abstract	BACKGROUND: Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin related (DC-SIGNR) can bind to the human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein and is thus important for the host-pathogen interaction in HIV-1 infection. Studies of the association between the variable number tandem repeat (VNTR) polymorphism of the DC-SIGNR gene and HIV-1 susceptibility have produced controversial results. METHODS AND FINDINGS: We conducted a meta-analysis of the data contained in the literature to clarify these findings. In total, 10 studies consisting of 2683 HIV-1 patients and 3263 controls (2130 healthy controls and 1133 HIV-1 exposed but seronegative (HESN) controls) were included. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were assessed in the main analyses. Further stratified analyses by ethnicity and sample size were performed. By dividing the controls into two groups, healthy controls and HIV-1 exposed but seronegative (HESN) controls, we explored different genetic models to detect any association between the VNTR polymorphism and predisposition to HIV-1 infection. The results showed that the 5-repeat allele carriers (OR = 0.84, 95% CI = 0.73–0.96) and the 5/5 homozygous (OR = 0.68, 95% CI = 0.50–0.93) had significantly reduced risk when using the HIV-1 exposed but seronegative (HESN) as controls. The stratified analyses by ethnicity and sample size confirmed these findings. However, a low to moderate degree of heterogeneity was also found across studies. CONCLUSIONS: Our findings demonstrate that the VNTR polymorphism of the DC-SIGNR gene is associated with a moderate effect on host susceptibility to HIV-1 infection. Similar to the 32-bp deletion in the chemokine receptor-5 gene (CCR5Δ32), the DC-SIGNR VNTR 5-repeat allele might have a role in resistance to HIV infection, particularly in Asian populations.
has issue date	2012-09-05(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0042972
bibo:pmid	22957026
has license	cc-by
sha1sum (hex)	bf0e3ed6e8fa4adbfacbf76e9fa2f5aa1ccdef19
schema:url	https://doi.org/10.1371/journal.pone.0042972
resource representing a document's title	The VNTR Polymorphism of the DC-SIGNR Gene and Susceptibility to HIV-1 Infection: A Meta-Analysis
has PubMed Central identifier	PMC3434151
has PubMed identifier	22957026
schema:publication	PLoS One
resource representing a document's body	covid:bf0e3ed6e8fa4adbfacbf76e9fa2f5aa1ccdef19#body_text
is schema:about of	named entity 'HIV-1 infection' covid:arg/bf0e3ed6e8fa4adbfacbf76e9fa2f5aa1ccdef19 named entity 'VARIABLE NUMBER TANDEM REPEAT' named entity 'DC-SIGNR' named entity 'META-ANALYSIS' named entity 'IMPORTANT' named entity 'DENDRITIC CELL' named entity 'ASSOCIATION' named entity 'VNTR' named entity 'GP120' named entity 'DC-SIGNR' named entity 'INTERCELLULAR ADHESION MOLECULE-3' named entity 'SUSCEPTIBILITY' named entity 'SPECIFIC' named entity 'RELATED' named entity 'BACKGROUND' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'STUDIES' named entity 'ENVELOPE GLYCOPROTEIN' named entity 'HAVE' named entity 'HOST-PATHOGEN INTERACTION' named entity 'POLYMORPHISM' named entity 'SUSCEPTIBILITY' named entity 'POLYMORPHISM' named entity 'GENE' named entity 'BIND' named entity 'GENE' named entity 'HIV-1 INFECTION' named entity 'HIV-1 INFECTION' named entity 'RESULTS' named entity 'HIV-1' named entity 'intercellular adhesion molecule' named entity 'host-pathogen interaction' named entity 'variable number tandem repeat' named entity 'produced' named entity 'host-pathogen interaction' named entity 'variable number tandem repeat' named entity 'human immunodeficiency virus-1' named entity 'gp120' named entity 'Meta-Analysis' named entity 'publication bias' named entity 'alleles' named entity 'meta-analysis' named entity 'VNTR' named entity 'high affinity' named entity 'Asian' named entity 'metaanalysis' named entity 'sexual contact' named entity 'HIV-1 infection' named entity 'glycoprotein' named entity 'genotypes' named entity 'HIV-1' named entity 'allelic' named entity 'high-risk' named entity 'Asian' named entity 'VNTR' named entity 'HIV-1' named entity 'AIDS' named entity 'HIV-1' named entity 'seronegative' named entity 'VNTR' named entity 'HIV-1' named entity 'HIV-1 infection' named entity 'HIV-1 infection' named entity 'HIV-1 infection' named entity 'epithelial cells' named entity 'polymorphism' named entity 'VNTR' named entity 'HIV-1' named entity 'meta-analysis' named entity 'extracellular domain' named entity 'acquired immunodeficiency syndrome' named entity 'p-value' named entity 'ligands' named entity 'genotypes' named entity 'HIV-1 infection' named entity 'allele'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software