About: The contribution of pre-symptomatic infection to the transmission dynamics of COVID-2019

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About: The contribution of pre-symptomatic infection to the transmission dynamics of COVID-2019 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The contribution of pre-symptomatic infection to the transmission dynamics of COVID-2019
Creator	Liu, Yang Funk, Sebastian Flasche, Stefan Hopkins, Johns Kong, Hong Akhmetzhanov, Hokkaido, Andrei Lee, Bloomberg
Source	Medline; PMC
abstract	Background: Pre-symptomatic transmission can be a key determinant of the effectiveness of containment and mitigation strategies for infectious diseases, particularly if interventions rely on syndromic case finding. For COVID-19, infections in the absence of apparent symptoms have been reported frequently alongside circumstantial evidence for asymptomatic or pre-symptomatic transmission. We estimated the potential contribution of pre-symptomatic cases to COVID-19 transmission. Methods: Using the probability for symptom onset on a given day inferred from the incubation period, we attributed the serial interval reported from Shenzen, China, into likely pre-symptomatic and symptomatic transmission. We used the serial interval derived for cases isolated more than 6 days after symptom onset as the no active case finding scenario and the unrestricted serial interval as the active case finding scenario. We reported the estimate assuming no correlation between the incubation period and the serial interval alongside a range indicating alternative assumptions of positive and negative correlation. Results: We estimated that 23% (range accounting for correlation: 12 – 28%) of transmissions in Shenzen may have originated from pre-symptomatic infections. Through accelerated case isolation following symptom onset, this percentage increased to 46% (21 – 46%), implying that about 35% of secondary infections among symptomatic cases have been prevented. These results were robust to using reported incubation periods and serial intervals from other settings. Conclusions: Pre-symptomatic transmission may be essential to consider for containment and mitigation strategies for COVID-19.
has issue date	2020-04-01(xsd:dateTime)
bibo:doi	10.12688/wellcomeopenres.15788.1
bibo:pmid	32685697
has license	cc-by
sha1sum (hex)	bd28ce4a069e119b0aa3fd66d9d55b12ae1aeeb1
schema:url	https://doi.org/10.12688/wellcomeopenres.15788.1
resource representing a document's title	The contribution of pre-symptomatic infection to the transmission dynamics of COVID-2019
has PubMed Central identifier	PMC7324944
has PubMed identifier	32685697
schema:publication	Wellcome Open Res
resource representing a document's body	covid:bd28ce4a069e119b0aa3fd66d9d55b12ae1aeeb1#body_text
is schema:about of	named entity 'COVID' named entity 'CONTAINMENT' named entity 'PRE' named entity 'INFECTIOUS DISEASES' named entity 'rely' named entity 'mitigation' named entity 'transmission' named entity 'infectious diseases' named entity 'Open Peer Review' named entity 'apparent' named entity 'serial interval' named entity 'incubation period' named entity 'epidemiology' named entity 'pre-symptomatic' named entity 'incubation time' named entity 'anecdotal evidence' named entity 'pre-symptomatic' named entity 'serial interval' named entity 'probability' named entity 'clinical symptoms' named entity 'influenza' named entity 'probability' named entity 'serial interval' named entity '8 days' named entity 'anti-correlated' named entity 'serial interval' named entity 'cruise ship' named entity 'correlation' named entity 'case finding' named entity 'World Health Organization' named entity 'COVID-19' named entity 'serial interval' named entity 'case finding' named entity 'pre-symptomatic' named entity 'social distancing' named entity 'serial interval' named entity 'correlation' named entity 'case finding' named entity 'case finding' named entity 'incubation period' named entity 'case finding' named entity 'case finding' named entity 'COVID' named entity 'anti-correlated' named entity 'serial interval' named entity 'pre-symptomatic' named entity 'symptom' named entity '11.3' named entity 'COVID-19' named entity '5.2' named entity 'infection' named entity 'SARS-CoV-2' named entity 'study design' named entity 'correlation' named entity 'case finding' named entity 'pre-symptomatic' named entity 'serial interval' named entity 'serial interval' named entity 'COVID' named entity 'pre-symptomatic' named entity 'serial interval' named entity 'pre-symptomatic' named entity 'asymptomatic' named entity 'COVID-19 infection' named entity 'health care workers' named entity 'serial interval' named entity 'case finding' named entity 'asymptomatic' named entity 'COVID' named entity 'non-specific' named entity 'influenza' named entity 'pre-symptomatic' named entity 'Shenzen' named entity 'non-specific symptoms'

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