About: Significance of liver dysfunction associated with decreased hepatic CT attenuation values in Japanese patients with severe COVID-19

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About: Significance of liver dysfunction associated with decreased hepatic CT attenuation values in Japanese patients with severe COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Significance of liver dysfunction associated with decreased hepatic CT attenuation values in Japanese patients with severe COVID-19
Creator	Tarumoto, Norihito Daisuke Hamada, • Maesaki, • Mochida, • Uchida, Yoshihito Uemura, Hayato Yamaba, Shinpei
source	Medline; PMC
abstract	BACKGROUND: COVID-19 has emerged as a threat to human health. Liver dysfunction has been reported to occur frequently in patients with COVID-19, although its significance has not yet been elucidated. METHODS: The subjects were 35 patients with COVID-19, and clinical characteristics were retrospectively analyzed. COVID-19 patients requiring ventilator were classified as having severe COVID-19. RESULTS: All 35 patients were diagnosed as having mild-to-moderate COVID-19 at admission, but the severity aggravated to severe in 8 patients (22.9%) in hospital. Hepatocellular-type liver injury, defined as elevation of the serum AST and/or ALT levels to ≥ 3 times the ULN, was seen in 2 patients (5.7%), and cholestasis-type liver injury, defined as elevation of the serum ALP, γ-GTP and/or total bilirubin levels to ≥ twice the ULN, was seen in 4 patients (11.4%). A total of 9 patients (25.7%) fulfilled the criteria for liver injury. The percentage of patients with liver injury was higher in patients with severe COVID-19 than in the remaining patients (P = 0.001). Both the hepatic CT attenuation values and the liver-to-spleen attenuation (L/S) ratios at admission were lower in the former patients than in the latter patients (P < 0.001). ROC curve revealed the optimal cut-off value of the L/S ratio of 1.03 for discriminating between patients with severe and non-severe diseases. The hepatic CT attenuation values increased at the remission phase of the disease as compared to the values at admission (P = 0.012). CONCLUSION: Liver dysfunction associated with reduced hepatic CT attenuation values correlated with the disease severity in patients with COVID-19.
has issue date	2020-08-09(xsd:dateTime)
bibo:doi	10.1007/s00535-020-01717-4
bibo:pmid	32776161
has license	no-cc
sha1sum (hex)	bce2ca6ebbaa8ecbe1107146adebc689dafb3ca8
schema:url	https://doi.org/10.1007/s00535-020-01717-4
resource representing a document's title	Significance of liver dysfunction associated with decreased hepatic CT attenuation values in Japanese patients with severe COVID-19
has PubMed Central identifier	PMC7415328
has PubMed identifier	32776161
schema:publication	J Gastroenterol
resource representing a document's body	covid:bce2ca6ebbaa8ecbe1107146adebc689dafb3ca8#body_text
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