About: Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: Behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal

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About: Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: Behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: Behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal
Creator	Broderick", Patricia Graduate School, York Jeannot3, Pierrot Omotola Hope3, Program, Mbrs
Source	Elsevier; Medline; PMC
abstract	Abstract 1. 1. Real time, in vivo microvoltammetric studies were performed, using miniature carbon-based sensors, to concurrently detect norepinephrine (NE) release and serotonin (5-HT) release, in 2 separate electrochemical signals, within CA1 region of hippocampus in the freely moving and behaving, male, Sprague Dawley laboratory rat. 2. 2. Concurrently, four parameters of open-field Behavior I.E. Ambulations, Rearing, Fine Movements and Central Ambulatory behavior (a measure of anxiety reduction behavior), were assayed by infrared photobeam detection. 3. 3. Time course studies showed that the mechanism of action of the triazolobenzodiazepine (TBZD), adinazolam, (Deracyn®) is dramatically different from that of the classical benzodiazepine (BZD), diazepam (Valium®) i.e., adinazolam increased, whereas diazepam decreased, 5-HT release within CA1 region of hippocampus in the freely moving and behaving rat. 4. 4. Adinazolam initially increased NE release and then decreased NE release in CA1 region of hippocampus in the freely moving and behaving rat whereas diazepam only decreased the electrochemical signal for NE; the decrease in NE produced by adinazolam was greater than the decrease in NE release produced by diazepam. 5. 5. The Behavioral Activity Patterns, derived from same animal controls, simultaneously with detection of in vivo microvoltammetric signals for NE release and 5-HT release, showed that the BZD, diazepam, exhibited more potent sedative properties than did the TBZD adinazolam. 6. 6. Hippocampal 5-HT and NE release effects of the TBZD, adinazolam, concomitant with behavioral effects lends explanation to the dual anxiolytic/antidepressant properties of the TBZDs.
has issue date	1998-02-28(xsd:dateTime)
bibo:doi	10.1016/s0278-5846(98)00010-4
bibo:pmid	9608607
has license	els-covid
sha1sum (hex)	bca8f636d21e772fb59e0ad2fcaa589b4357e083
schema:url	https://doi.org/10.1016/s0278-5846%2898%2900010-4
resource representing a document's title	Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: Behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal
has PubMed Central identifier	PMC7131360
has PubMed identifier	9608607
schema:publication	Progress in Neuro-Psychopharmacology and Biological Psychiatry
resource representing a document's body	covid:bca8f636d21e772fb59e0ad2fcaa589b4357e083#body_text
is schema:about of	named entity 'ANXIETY' named entity 'NOREPINEPHRINE' named entity 'SEROTONIN RELEASE' named entity 'HIPPOCAMPAL' named entity 'CONCOMITANT' named entity 'BENZODIAZEPINE' named entity 'PATRICIA' named entity 'STUDIES' named entity 'CA1' named entity 'DEPRESSION' named entity 'ACTION' named entity 'DETECTION' named entity 'ANIMAL' named entity 'MECHANISM' named entity 'BEHAVIORAL' named entity 'SEROTONIN' named entity 'ANXIETY' named entity 'ANIMAL' named entity '5-HT' named entity 'platelet activating factor' named entity 'diazepam' named entity 'GABA-A' named entity 'regression analysis' named entity 'Ramon y Cajal' named entity 'biphasic' named entity 'alprazolam' named entity 'high affinity' named entity 'endogenous' named entity '5-HT' named entity '5-HT' named entity 'anxiolytic' named entity 'habituated' named entity 'adinazolam' named entity 'diazepam' named entity 'autoreceptor' named entity '5-HT' named entity 'physiological' named entity '5-HT' named entity 'ANOVA' named entity 'adinazolam' named entity 'adinazolam' named entity 'Diazepam' named entity 'diazepam' named entity 'adinazolam' named entity 'lorazepam' named entity 'depression' named entity 'nerve cell' named entity '5-HT' named entity 'BZD' named entity 'adinazolam' named entity 'sedative' named entity 'chloral hydrate' named entity 'Fine Movement' named entity '5-HT' named entity 'Adinazolam' named entity 'antidepressant' named entity 'controlled studies' named entity '5-HT' named entity 'neuroanatomical' named entity 'statistically significant' named entity 'adinazolam' named entity 'rat' named entity '5-HT' named entity 'thigmotactic' named entity 'BZD' named entity 'adinazolam' named entity 'neuronal firing' named entity 'potentiostat' named entity '5-HT' named entity 'Nerve cell' named entity 'statistically significant' named entity 'anxiety' named entity 'anxiety' named entity 'adinazolam' named entity 'presynaptic' named entity 'Jacoby' named entity 'gammabutyrolactone'

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