About: Neurobiology of coronaviruses: Potential relevance for COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neurobiology of coronaviruses: Potential relevance for COVID-19
Creator	Taglialatela, Maurizio Cataldi, Mauro Pignataro, Giuseppe
Source	Elsevier; Medline; PMC
abstract	In the first two decades of the 21st century, there have been three outbreaks of severe respiratory infections caused by highly pathogenic coronaviruses (CoVs) around the world: the severe acute respiratory syndrome (SARS) by the SARS-CoV in 2002–2003, the Middle East respiratory syndrome (MERS) by the MERS-CoV in June 2012, and Coronavirus Disease 2019 (COVID-19) by the SARS-CoV-2 presently affecting most countries In all of these, fatalities are a consequence of a multiorgan dysregulation caused by pulmonary, renal, cardiac, and circulatory damage; however, COVID patients may show significant neurological signs and symptoms such as headache, nausea, vomiting, and sensory disturbances, the most prominent being anosmia and ageusia. The neuroinvasive potential of CoVs might be responsible for at least part of these symptoms and may contribute to the respiratory failure observed in affected patients. Therefore, in the present manuscript, we have reviewed the available preclinical evidence on the mechanisms and consequences of CoVs-induced CNS damage, and highlighted the potential role of CoVs in determining or aggravating acute and long-term neurological diseases in infected individuals. We consider that a widespread awareness of the significant neurotropism of CoVs might contribute to an earlier recognition of the signs and symptoms of viral-induced CNS damage. Moreover, a better understanding of the cellular and molecular mechanisms by which CoVs affect CNS function and cause CNS damage could help in planning new strategies for prognostic evaluation and targeted therapeutic intervention.
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1016/j.nbd.2020.105007
bibo:pmid	32622086
has license	no-cc
sha1sum (hex)	bbcbb0bcba37ee19c283531060ff38a1cf2177a7
schema:url	https://doi.org/10.1016/j.nbd.2020.105007
resource representing a document's title	Neurobiology of coronaviruses: Potential relevance for COVID-19
has PubMed Central identifier	PMC7329662
has PubMed identifier	32622086
schema:publication	Neurobiol Dis
resource representing a document's body	covid:bbcbb0bcba37ee19c283531060ff38a1cf2177a7#body_text
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