About: Amelioration of oxidative stress using N‐acetylcysteine in canine parvoviral enteritis

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About: Amelioration of oxidative stress using N‐acetylcysteine in canine parvoviral enteritis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Amelioration of oxidative stress using N‐acetylcysteine in canine parvoviral enteritis
Creator	Chethan, \| De, \| Garkhal, \| Gaykwad, C Nandi, \|
Source	Medline; PMC
abstract	Previously, antioxidants have not been evaluated for treatment of parvoviral diarrhea in dogs. In this study, antioxidant potential of N‐acetylcysteine (NAC) in dogs infected with canine parvovirus with a nonblinded randomized clinical trial has been carried out. A total 18 parvo‐infected dogs were randomly divided into two groups: nine parvo‐infected dogs were treated with supportive treatment and nine parvo‐infected dogs were treated with NAC along with supportive treatment. Simultaneously, nine healthy dogs were kept as healthy control. In parvo‐infected dogs, marked hemoconcentration, leucopenia, neutropenia and oxidative stress were noticed compared to healthy dogs. The NAC treatment progressively improved the leukocyte, neutrophil, monocyte, and eosinophil counts over the time in parvovirus‐infected dogs compared to dogs that received only supportive treatment. In addition, NAC treatment significantly improved glutathione S‐transferase (GST) activity and decreased nitrite plus nitrate (NOx) and malondialdehyde (MDA) concentrations on day 3 and 5 compared to supportive treatment in parvo‐infected dogs. However, supportive treatment alone failed to ameliorate oxidative stress in the infected dogs till day 5. The results of this study suggest that NAC represents a potential additional treatment option that could be considered to improve the health condition and minimize the duration of hospitalization in case of canine parvoviral diarrhea.
has issue date	2017-07-12(xsd:dateTime)
bibo:doi	10.1111/jvp.12434
bibo:pmid	28703421
has license	no-cc
sha1sum (hex)	bb7b71afa6bd3f8a84c59e94439ad6f7b721f20a
schema:url	https://doi.org/10.1111/jvp.12434
resource representing a document's title	Amelioration of oxidative stress using N‐acetylcysteine in canine parvoviral enteritis
has PubMed Central identifier	PMC7166929
has PubMed identifier	28703421
schema:publication	J Vet Pharmacol Ther
resource representing a document's body	covid:bb7b71afa6bd3f8a84c59e94439ad6f7b721f20a#body_text
is schema:about of	named entity 'oxidative stress' named entity 'leukocyte' named entity 'dogs' named entity 'duration' named entity 'HEALTH CONDITION' named entity 'HEMOCONCENTRATION' named entity 'COULD BE' named entity 'COMPARED' named entity 'IMPROVED' named entity 'nitrate' named entity 'dogs' named entity 'hospitalization' named entity 'antioxidants' named entity 'parvovirus' named entity 'total' named entity 'control' named entity 'p-value' named entity 'anion' named entity 'reduced appetite' named entity 'primers' named entity 'neutropenia' named entity 'N-acetylcysteine' named entity 'anemia' named entity 'Canine parvovirus' named entity 'oxidation' named entity 'antioxidant enzymes' named entity 'nitrogen species' named entity 'recombinant' named entity 'pmol' named entity 'plasma' named entity 'oxidative stress' named entity 'rotavirus' named entity 'Post Hoc test' named entity 'NOx' named entity 'hemoconcentration' named entity 'Rajkarnikar' named entity 'erythrocyte' named entity 'lipid peroxidation' named entity 'sequenced' named entity 'one-way ANOVA' named entity 'PCR' named entity 'PCR' named entity 'electrophoresis' named entity 'dye' named entity 'sodium acetate' named entity 'Applied Biosystems' named entity 'higher concentration' named entity 'primers' named entity 'eosinophil' named entity 'agarose gel' named entity 'neutropenia' named entity 'PCR' named entity 'statistically significant' named entity 'TCA' named entity 'parvo' named entity 'polyunsaturated fatty acids' named entity 'metabolic' named entity 'dehydration' named entity 'lymphocyte' named entity 'NOx' named entity 'antioxidant' named entity 'negative control' named entity 'malondialdehyde' named entity 'porcine reproductive and respiratory syndrome' named entity 'nitrate' named entity 'herpesvirus' named entity 'influenza' named entity 'nuclease' named entity 'case' named entity 'N-acetylcysteine' named entity 'parvo' named entity 'parvo' named entity 'NOx' named entity 'supportive treatment' named entity 'supportive treatment' named entity 'monocyte' named entity 'denaturation'

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