About: Evidence for Human Norovirus Infection of Dogs in the United Kingdom

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evidence for Human Norovirus Infection of Dogs in the United Kingdom
Creator	Brownlie, Joe Le Pendu, Jacques Goodfellow, Ian Emmott, Edward Caddy, Sarah El-Attar, Laila Mitchell, Judy Belliot, Gael Hollinshead, Michael De Rougemont, Alexis
Source	Medline; PMC
abstract	Human noroviruses (HuNoVs) are a major cause of viral gastroenteritis, with an estimated 3 million cases per year in the United Kingdom. HuNoVs have recently been isolated from pet dogs in Europe (M. Summa, C.-H. von Bonsdorff, and L. Maunula, J Clin Virol 53:244–247, 2012, http://dx.doi.org/10.1016/j.jcv.2011.12.014), raising concerns about potential zoonotic infections. With 31% of United Kingdom households owning a dog, this could prove to be an important transmission route. To examine this risk, canine tissues were studied for their ability to bind to HuNoV in vitro. In addition, canine stool samples were analyzed for the presence of viral nucleic acid, and canine serum samples were tested for the presence of anti-HuNoV antibodies. The results showed that seven different genotypes of HuNoV virus-like particles (VLPs) can bind to canine gastrointestinal tissue, suggesting that infection is at least theoretically possible. Although HuNoV RNA was not identified in stool samples from 248 dogs, serological evidence of previous exposure to HuNoV was obtained in 43/325 canine serum samples. Remarkably, canine seroprevalence for different HuNoV genotypes mirrored the seroprevalence in the human population. Though entry and replication within cells have not been demonstrated, the canine serological data indicate that dogs produce an immune response to HuNoV, implying productive infection. In conclusion, this study reveals zoonotic implications for HuNoV, and to elucidate the significance of this finding, further epidemiological and molecular investigations will be essential.
has issue date	2015-05-14(xsd:dateTime)
bibo:doi	10.1128/jcm.02778-14
bibo:pmid	25832298
has license	cc-by
sha1sum (hex)	bb76fcd0194eeda7dc70702dacad97492a497bea
schema:url	https://doi.org/10.1128/jcm.02778-14
resource representing a document's title	Evidence for Human Norovirus Infection of Dogs in the United Kingdom
has PubMed Central identifier	PMC4432062
has PubMed identifier	25832298
schema:publication	J Clin Microbiol
resource representing a document's body	covid:bb76fcd0194eeda7dc70702dacad97492a497bea#body_text
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