About: Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?
Creator	Giovagnoli, Stefano Puccetti, Matteo Ricci, Maurizio Xiroudaki, Styliani
Source	Medline; PMC
abstract	Mismanagement of bacterial infection therapies has undermined the reliability and efficacy of antibiotic treatments, producing a profound crisis of the antibiotic drug market. It is by now clear that tackling deadly infections demands novel strategies not only based on the mere toxicity of anti-infective compounds. Host-directed therapies have been the first example as novel treatments with alternate success. Nevertheless, recent advances in the human microbiome research have provided evidence that compounds produced by the microbial metabolism, namely postbiotics, can have significant impact on human health. Such compounds target the host-microbe-pathogen interface rescuing biotic and immune unbalances as well as inflammation, thus providing novel therapeutic opportunities. This work discusses critically, through literature review and personal contributions, these novel nonantibiotic treatment strategies for infectious disease management and resistance prevention, which could represent a paradigm change rocking the foundation of current antibiotic therapy tenets.
has issue date	2020-07-04(xsd:dateTime)
bibo:doi	10.3390/pharmaceutics12070624
bibo:pmid	32635461
has license	cc-by
sha1sum (hex)	ba908985b472c0dc96fc9305642028b45e54cc44
schema:url	https://doi.org/10.3390/pharmaceutics12070624
resource representing a document's title	Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?
has PubMed Central identifier	PMC7408102
has PubMed identifier	32635461
schema:publication	Pharmaceutics
resource representing a document's body	covid:ba908985b472c0dc96fc9305642028b45e54cc44#body_text
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