About: A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors

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About: A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors
Creator	Huang, Yi Wu, Feng Lao, Lixing Meng, Xian-Ze Pang, Bin Qin, Zhi-Feng Shi, Jun Sun, Da-Zhi Wei, Pin-Kang Xiu, Li-Juan
Source	PMC
abstract	Introduction. Posttraumatic stress disorder (PTSD) is accompanied by poor general psychological status (GPS). In the present study, we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD. Methods. A randomized, double-blind, placebo-controlled trial compared a Chinese herbal formula, Xiao-Tan-Jie-Yu-Fang (XTJYF), to placebo in 2008 Sichuan earthquake survivors with PTSD. Patients were randomized into XTJYF (n = 123) and placebo (n = 122) groups. Baseline-to-end-point score changes in the three global indices of the Symptom Checklist-90-Revised (SCL-90-R) and rates of response in the SCL global severity index (GSI) were the primary endpoints. A subanalysis of the nine SCL factors and the sleep quality score were secondary endpoints. Results and Discussion. Compared to placebo, the XTJYF group was significantly improved in all three SCL global indices (P = 0.001~0.028). More patients in the XTJYF group reported “much improved” than the placebo group (P = 0.001). The XTJYF group performed significantly better than control in five out of nine SCL factors (somatization, obsessive-compulsive behavior, depression, anxiety, and hostility (P = 0.001~0.036)), and in sleep quality score (P < 0.001). XTJYF produced no serious adverse events. These findings suggest that XTJYF may be an effective and safe treatment option for improving GPS in patients with PTSD.
has issue date	2011-10-19(xsd:dateTime)
bibo:doi	10.1155/2012/691258
bibo:pmid	22028733
has license	cc-by
sha1sum (hex)	b9ac24a16dd729a1db737ead634eaa577b00febd
schema:url	https://doi.org/10.1155/2012/691258
resource representing a document's title	A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors
has PubMed Central identifier	PMC3199055
has PubMed identifier	22028733
schema:publication	Evid Based Complement Alternat Med
resource representing a document's body	covid:b9ac24a16dd729a1db737ead634eaa577b00febd#body_text
is schema:about of	named entity 'HERBAL' named entity 'PLACEBO-CONTROLLED TRIAL' named entity 'METHODS' named entity 'PSYCHOLOGICAL' named entity 'MAY BE' named entity 'INVESTIGATED' named entity 'SURVIVORS' named entity 'SCORE' named entity 'SLEEP QUALITY' named entity 'TAN' named entity '028' named entity 'SEVERITY' named entity 'THESE' named entity 'PERFORMED' named entity 'CHANGES' named entity 'RATES' named entity 'INTRODUCTION' named entity 'EFFECTS' named entity 'GROUP' named entity 'DEPRESSION' named entity 'INDICES' named entity 'FANG' named entity 'FORMULA' named entity 'PATIENTS' named entity 'SERIOUS ADVERSE EVENTS' named entity 'ANXIETY' named entity 'SYMPTOM CHECKLIST-90-REVISED ' named entity 'TREATMENT OPTION' named entity 'HOSTILITY' named entity 'EFFECTIVE' named entity 'DISCUSSION' named entity 'PLACEBO' named entity 'SAFE' named entity 'PTSD' named entity 'GLOBAL' named entity 'DOUBLE' named entity 'GENERAL' named entity 'BEHAVIOR' named entity 'STATUS' named entity 'CHINESE' named entity 'SURVIVORS' named entity 'BLIND' named entity 'RESULTS' named entity '28P' named entity 'CONTROL' named entity 'PRIMARY' named entity 'INDEX' named entity 'IMPROVED' named entity 'FINDINGS' named entity 'POSTTRAUMATIC STRESS DISORDER' named entity 'FORMULA' named entity 'STUDY' named entity 'STATUS' named entity 'RANDOMIZED PLACEBO-CONTROLLED TRIAL' named entity 'SECONDARY' named entity 'POOR' named entity 'ENDPOINTS' named entity '036' named entity 'COMPARED' named entity 'POSTTRAUMATIC STRESS DISORDER' named entity 'GROUPS' named entity '0.001' named entity 'HERBAL' named entity 'RESPONSE' named entity 'SCL' named entity 'EARTHQUAKE' named entity 'GENERAL' named entity 'IMPROVING' named entity 'CHINESE' named entity 'SUGGEST' named entity 'END-POINT' named entity 'PRESENT'

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