About: SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors

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About: SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors
Creator	Ivanov, Alexander Efimov, Grigory Titov, Aleksei Shugay, Mikhail Bagaev, Dmitry Biderman, Bella Dianov, Dmitry Khamaganova, Ekaterina Khmelevskaya, Alexandra Kiryukhin, Dmitriy Malasheva, Maria Maleeva, Alexandra Malko, Dmitry Peshkova, Iuliia Pilunov, Artem Pivnyuk, Anastasia Serdyuk, Yana Shakirova, Naina Shcherbinin, Dmitrii Sheetikov, Savely Shmelev, Anton Shomuradova, Alina Vagida, Murad Zornikova, Ksenia
Source	MedRxiv
abstract	Understanding the determinants of adaptive immune response to SARS-CoV-2 is critical for fighting the ongoing COVID-19 pandemic. Here we assayed both antibody and T-cell reactivity to SARS-CoV-2 antigens in COVID-19 convalescent patients and healthy donors sampled before and during the pandemic. Our results show that while anti-SARS-CoV-2 antibodies can distinguish convalescent patients from healthy donors, the magnitude of T-cell response was more pronounced in healthy donors sampled during COVID-19 pandemic than in donors sampled before the outbreak. This hints at the possibility that some individuals have encountered the virus but were protected by T-cell cross-reactivity observed. A public and diverse T-cell response was observed for two A*02-restricted SARS-CoV-2 epitopes, revealing a set of T-cell receptor motifs displaying germline-encoded features. Bulk CD4+ and CD8+ T-cell response to SARS-CoV-2 glycoprotein S is characterized by multiple groups of homologous T-cell receptor sequences some of which are shared across multiple donors, indicating the existence of immunodominant epitopes. Overall, our findings indicate that T cells form an efficient response to SARS-CoV-2 and alongside the antibodies can serve as a useful biomarker for surveying SARS-CoV-2 exposure and immunity. We hope that data, including the set of specific T-cell receptors identified in this study can serve as a basis for future developments of SARS-CoV-2 vaccinations and monitoring.
has issue date	2020-05-25(xsd:dateTime)
bibo:doi	10.1101/2020.05.20.20107813
has license	medrxiv
sha1sum (hex)	b8b5da1bfaf2299e0e8b5008fd13a607bf2638b4
schema:url	https://doi.org/10.1101/2020.05.20.20107813
resource representing a document's title	SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors
resource representing a document's body	covid:b8b5da1bfaf2299e0e8b5008fd13a607bf2638b4#body_text
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