About: Mimicry of human IgE epitopes by anti-idiotypic antibodies 1 1 Edited by I. A. Wilson

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mimicry of human IgE epitopes by anti-idiotypic antibodies 1 1 Edited by I. A. Wilson
Creator	Effenberger, Friedrich Kricek, Franz Kuhn, Sonja Miescher, Sylvia Ruf, Christine Vogel, Monique Rcher, È Stadler, Beda Stadler, Michael Zu, Adrian
Source	Elsevier; Medline; PMC
abstract	Abstract According to Jerne’s network hypothesis, the binding site of an anti-idiotypic antibody also represents the internal image of an epitope present on a foreign, or even a self antigen. In recent years, antigen mimicry has been defined at the molecular level for some xeno-antigens. However, until now there has been no demonstration of structural mimicry between a human anti-idiotypic antibody and a self structure. To address this question, we used human IgE as the self structure and a well-defined anti-human IgE mAb (BSW17). We describe the isolation of two anti- idiotypic antibodies specific for the anti-IgE antibody BSW17 from a non-immune human Fab phage display library. Interestingly, these two anti-idiotypic antibodies mimic the same molecular surface region as a previously described IgE peptide mimotope isolated by panning on BSW17, but they cover a much larger epitope on the IgE molecule. Accordingly, immunisation of rabbits with the two anti-idiotypic antibodies induced high-affinity antibodies with the same characteristics as BSW17. Thus, our data demonstrate that it is possible to isolate anti-idiotypic antibodies derived from the human genome without the need for hyperimmunisation, and confirm Jerne’s hypothesis that both foreign antigens and self structures can be mimicked by our own immunoglobulins.
has issue date	2000-05-19(xsd:dateTime)
bibo:doi	10.1006/jmbi.2000.3713
bibo:pmid	10801344
has license	els-covid
sha1sum (hex)	b83c109787fc758361cbea286748f5f8016ede03
schema:url	https://doi.org/10.1006/jmbi.2000.3713
resource representing a document's title	Mimicry of human IgE epitopes by anti-idiotypic antibodies 1 1 Edited by I. A. Wilson
has PubMed Central identifier	PMC7125776
has PubMed identifier	10801344
schema:publication	Journal of Molecular Biology
resource representing a document's body	covid:b83c109787fc758361cbea286748f5f8016ede03#body_text
is schema:about of	named entity 'ANTIBODIES' named entity 'MIMICRY' named entity 'DEMONSTRATION' named entity 'MOLECULAR' named entity 'RABBITS' named entity 'HYPOTHESIS' named entity 'MAB' named entity 'CHARACTERISTICS' named entity 'FOREIGN' named entity 'ANTIGEN' named entity 'ANTIGENS' named entity 'HUMAN' named entity 'INDUCED' named entity 'AEC' named entity 'SURFACE REGION' named entity 'MOLECULE' named entity 'LARGER' named entity 'MIMIC' named entity 'XENO' named entity 'MUCH' named entity 'ISOLATION' named entity 'IGE' named entity 'HUMAN' named entity 'ANTIBODIES' named entity 'PEPTIDE' named entity 'IMAGE' named entity 'NETWORK' named entity 'PRESENT' named entity 'MIMICRY' named entity 'MIMOTOPE' named entity 'ACCORDING' named entity 'HIGH' named entity 'SELF ANTIGEN' named entity 'POSSIBLE' named entity 'BINDING SITE' named entity 'ADDRESS' named entity 'EPITOPE' named entity 'RECENT' named entity 'PANNING' named entity 'YEARS' named entity 'NEED FOR' named entity 'EPITOPES' named entity 'DESCRIBE' named entity 'SELF' named entity 'INTERNAL' named entity 'THESE' named entity 'PREVIOUSLY' named entity 'ANTI-IGE ANTIBODY' named entity 'QUESTION' named entity 'DATA' named entity 'IMMUNOGLOBULINS' named entity 'PHAGE DISPLAY LIBRARY' named entity 'DESCRIBED' named entity 'IGE' named entity 'ANTIBODY' named entity 'COVER' named entity 'STRUCTURES' named entity 'SITE OF' named entity 'ISOLATED' named entity 'IMMUNISATION' named entity 'USED' named entity 'BUT' named entity 'FAB' named entity 'LEVEL' named entity 'OUR' named entity 'HUMAN GENOME' named entity 'STRUCTURE' named entity 'NON-IMMUNE HUMAN' named entity '27S' named entity 'STRUCTURAL' named entity 'DERIVED' named entity 'ISOLATE'

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