About: Modeling Brain Tumors Using Avian Retroviral Gene Transfer

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Modeling Brain Tumors Using Avian Retroviral Gene Transfer
Creator	Holland, Eric Holland, Tod
Source	PMC
abstract	RCAS/tv-a is a system for postnatal cell-type-specific gene transfer. It is used for the modeling of gliomas and medulloblastomas. This system provides a combination of lineage tracing from the cell origin with oncogenesis induced by mis-expression of specific genes. The genes that are most potent at inducing tumors are those that encode components of signal transduction and undifferentiated cells are most capable of serving as the cell of origin. The system effectively generates tumors with the histologic characteristics of human disease. Mice bearing RCAS/tv-a-induced brain tumors are currently being used for preclinical trials to understand the biology of therapeutic response in the various cell types that make up gliomas and medulloblastomas.
has issue date	2008-12-12(xsd:dateTime)
bibo:doi	10.1007/978-1-60327-553-8_2
has license	no-cc
sha1sum (hex)	b8169000e440aa5603fa70192ce4986b4b85f90c
schema:url	https://doi.org/10.1007/978-1-60327-553-8_2
resource representing a document's title	Modeling Brain Tumors Using Avian Retroviral Gene Transfer
has PubMed Central identifier	PMC7122153
schema:publication	CNS Cancer
resource representing a document's body	covid:b8169000e440aa5603fa70192ce4986b4b85f90c#body_text
is schema:about of	named entity 'tumors' named entity 'postnatal' named entity 'medulloblastomas' named entity 'GENES' named entity 'INDUCING' named entity 'TYPE' named entity 'tumors' named entity 'cells' named entity 'generates' named entity 'gliomas' named entity 'response' named entity 'human' named entity 'brain tumors' named entity 'cell' named entity 'oncogenesis' named entity 'histologic' named entity 'gene transfer' named entity 'Retroviral' named entity 'Reverse transcriptase' named entity 'PDGF' named entity 'cancer-causing viruses' named entity 'glycoproteins' named entity 'GFAP' named entity 'RSV' named entity 'glycoproteins' named entity 'granule cell layer' named entity 'reverse transcriptase' named entity 'floxed' named entity 'RCAS' named entity 'retroviruses' named entity 'sarcoma' named entity 'tumor suppressor' named entity 'virus' named entity 'gene products' named entity 'host cell' named entity 'tumor' named entity 'mammalian cells' named entity 'secretory pathway' named entity 'Medulloblastomas' named entity 'SHH' named entity 'mammal' named entity 'CNS' named entity 'tumors' named entity 'myc' named entity 'pathogen' named entity 'retroviruses' named entity 'RCAS' named entity 'retroviruses' named entity 'malignant' named entity 'retroviruses' named entity 'nucleocapsid' named entity 'nucleocapsid' named entity 'nestin' named entity 'tumor' named entity 'receptor' named entity 'Ras' named entity 'rhombic lip' named entity 'tumor formation' named entity 'co-activation' named entity 'Retroviruses' named entity 'RCAS' named entity 'Akt' named entity 'Temozolomide' named entity 'nucleic acids' named entity 'gene promoter' named entity 'E2F1' named entity 'single cell' named entity 'floxed' named entity 'luciferin' named entity 'James Watson' named entity 'cell surface receptor' named entity 'RCAS' named entity 'SHH signaling pathway' named entity 'p53' named entity 'LTR' named entity 'transgenic mice' named entity 'viral proteins' named entity 'PDGF' named entity 'RCAS' named entity 'gliomas' named entity 'tumors' named entity 'RNA'

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