About: Triclosan and triclocarban exposure, infectious disease symptoms and antibiotic prescription in infants—A community-based randomized intervention

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About: Triclosan and triclocarban exposure, infectious disease symptoms and antibiotic prescription in infants—A community-based randomized intervention Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Triclosan and triclocarban exposure, infectious disease symptoms and antibiotic prescription in infants—A community-based randomized intervention
Creator	Desai, Manisha Ley, Catherine Parsonnet, Julie Sundaram, Vandana De La Luz Sanchez, Maria
source	PMC
abstract	BACKGROUND: Triclosan and triclocarban (TCs) are broad-spectrum antimicrobials that, until recently, were found in a wide variety of household and personal wash products. Popular with consumers, TCs have not been shown to protect against infectious diseases. OBJECTIVES: To determine whether use of TC-containing wash products reduces incidence of infection in children less than one year of age. METHODS: Starting in 2011, we nested a randomized intervention of wash products with and without TCs within a multiethnic birth cohort. Maternal reports of infectious disease symptoms and antibiotic use were collected weekly by automated survey; household visits occurred every four months. Antibiotic prescriptions were identified by medical chart review. Urinary triclosan levels were measured in a participant subset. Differences by intervention group in reported infectious disease (primary outcome) and antibiotic use (secondary outcome) were assessed using mixed effects logistic regression and Fisher’s Exact tests, respectively. RESULTS: Infectious illness occurred in 6% of weeks, with upper respiratory illness the predominant syndrome. Among 60 (45%) TC-exposed and 73 (55%) non-TC-exposed babies, infectious disease reports did not differ in frequency between groups (likelihood ratio test: p = 0.88). Medical visits with antibiotic prescriptions were less common in the TC group than in the non-TC group (7.8% vs. 16.6%, respectively; p = 0.02). CONCLUSIONS: Although randomization to TC-containing wash products was not associated with decreased infectious disease reports by mothers, TCs were associated with decreased antibiotic prescriptions, suggesting a benefit against bacterial infection. The recent removal of TCs from consumer wash products makes further elucidation of benefits and risks impracticable.
has issue date	2018-06-28(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0199298
bibo:pmid	29953463
has license	cc-by
sha1sum (hex)	b5b3d491ce72ba843d589539a807b0cf32946849
schema:url	https://doi.org/10.1371/journal.pone.0199298
resource representing a document's title	Triclosan and triclocarban exposure, infectious disease symptoms and antibiotic prescription in infants—A community-based randomized intervention
has PubMed Central identifier	PMC6023107
has PubMed identifier	29953463
schema:publication	PLoS One
resource representing a document's body	covid:b5b3d491ce72ba843d589539a807b0cf32946849#body_text
is schema:about of	named entity 'symptoms' named entity 'HOUSEHOLD' named entity 'INFECTIOUS DISEASE' named entity 'RECENTLY' named entity 'SPECTRUM' named entity 'RANDOMIZED INTERVENTION' named entity 'BROAD' named entity 'SYMPTOMS' named entity 'ANTIBIOTIC' named entity 'BASED' named entity 'COMMUNITY' named entity 'TRICLOSAN' named entity 'WASH' named entity 'VARIETY' named entity 'PERSONAL' named entity 'CONSUMERS' named entity 'ANTIMICROBIALS' named entity 'HAVE' named entity 'TRICLOCARBAN' named entity 'INFECTIOUS DISEASES' named entity 'PRODUCTS' named entity 'TCS' named entity 'WIDE' named entity 'FOUND' named entity 'PRESCRIPTION' named entity 'TRICLOSAN' named entity 'INFANTS' covid:arg/b5b3d491ce72ba843d589539a807b0cf32946849 named entity 'products' named entity 'broad-spectrum' named entity 'birth cohort' named entity 'antibiotic' named entity 'immunology' named entity 'pregnancy' named entity 'San Jose' named entity 'toothpaste' named entity 'infectious disease' named entity 'liquid-liquid extraction' named entity 'antibiotic' named entity 'infectious disease' named entity 'antibiotic' named entity 'triclosan' named entity 'microbial flora' named entity 'correlation' named entity 'infection' named entity 'logistic regression' named entity 'triclosan' named entity 'antibiotics' named entity 'toothpaste' named entity 'liquid soaps' named entity 'REDCap' named entity 'bar soap' named entity 'illness symptoms' named entity 'triclosan' named entity 'triclosan' named entity 'Translational Research' named entity 'infectious diseases' named entity 'pregnant mothers' named entity 'cohort study' named entity 'cellulitis' named entity 'Phi coefficient' named entity 'anti-bacterial' named entity 'Loss to follow-up' named entity 'block size' named entity 'follow-up' named entity 'SAS' named entity '20 mothers' named entity 'Palo Alto' named entity 'antibiotics' named entity 'ethyl acetate' named entity 'antibiotic' named entity 'infection' named entity 'quartile' named entity 'immunomodulatory' named entity 'infectious disease' named entity 'Toothpastes' named entity 'microbiota'

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