About: Antigenic variation among murine coronaviruses: Evidence for polymorphism on the peplomer glycoprotein, E2

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About: Antigenic variation among murine coronaviruses: Evidence for polymorphism on the peplomer glycoprotein, E2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antigenic variation among murine coronaviruses: Evidence for polymorphism on the peplomer glycoprotein, E2
Creator	Talbot, Pierre Buchmeier, Michael
Source	Elsevier; Medline; PMC
abstract	Abstract A panel of 28 monoclonal antibodies (MAb) against the structural proteins of murine hepatitis virus-4, strain JHM (MHV-4) was used in three antigen binding assays to determine the extent of antigenic homology among six strains of murine coronaviruses. The antigenic determinants studied were highly conserved on the E1 glycoproteins and nucleocapsid (N) proteins of all strains tested. In contrast, antigenic polymorphism was observed among the E2 glycoproteins. Of three previously described antigenic determinants against which neutralizing antibodies are directed, only one, termed A(E2), was conserved on all strains. Antigenic site B(E2) was found only on the strongly neurotropic MHV-4 and site C(E2) was present on the virulent MHV-4 and MHV-3 (hepatotropic) strains, but absent on the weakly pathogenic MHV-A59, MHV-1 and MHV-S strains. Four non-neutralizing antibodies against at least one topographically distinct antigenic determinant, which we previously designated D(E2), gave binding patterns consistent with two distinct sites. One of these was present on all MHV strains tested and the other was present on all strains except MHV-S. These non-neutralizing antigenic sites were redesignated E(E2) and D(E2) respectively.
has issue date	1985-06-30(xsd:dateTime)
bibo:doi	10.1016/0168-1702(85)90028-0
bibo:pmid	2412363
has license	els-covid
sha1sum (hex)	b48dbc4c8d363fb48dbf7f6b7ca9c2591720e92b
schema:url	https://doi.org/10.1016/0168-1702%2885%2990028-0
resource representing a document's title	Antigenic variation among murine coronaviruses: Evidence for polymorphism on the peplomer glycoprotein, E2
has PubMed Central identifier	PMC7133991
has PubMed identifier	2412363
schema:publication	Virus Research
resource representing a document's body	covid:b48dbc4c8d363fb48dbf7f6b7ca9c2591720e92b#body_text
is schema:about of	named entity 'strains' named entity 'polymorphism' named entity 'MONOCLONAL ANTIBODIES' named entity 'FOUND' named entity 'ONE OF' named entity 'CORONAVIRUS' named entity 'USED' named entity 'EXTENT OF' named entity 'EXCEPT' named entity 'STRAIN' named entity 'BINDING' named entity 'NON-' named entity 'MURINE' named entity 'THESE' named entity 'CONTRAST' named entity 'TESTED' named entity 'PROTEINS' named entity 'VIRULENT' named entity 'STRAINS' named entity 'STRUCTURAL PROTEINS' named entity 'GAVE' named entity 'ANTIGENIC DETERMINANTS' named entity 'CONSERVED' named entity 'BUT' named entity 'EVIDENCE FOR' named entity 'ANTIGEN' named entity 'HIGHLY' named entity 'PATHOGENIC' named entity 'NEUTRALIZING ANTIBODIES' named entity 'PATTERNS' named entity 'MHV-1' named entity 'A59' named entity 'CONSISTENT WITH' named entity 'EPITOPE' named entity 'PRESENT' named entity 'DISTINCT' named entity 'MHV-S' named entity 'MURINE HEPATITIS VIRUS' named entity 'MURINE' named entity 'GLYCOPROTEIN' named entity 'ANTIGENIC VARIATION' named entity 'PREVIOUSLY' named entity 'NUCLEOCAPSID' named entity 'DIRECTED' named entity 'PANEL' named entity 'ANTIGENIC DETERMINANT' named entity 'DESIGNATED' named entity 'HOMOLOGY' named entity 'GLYCOPROTEINS' named entity 'SITE' named entity 'NEUROTROPIC' named entity 'BINDING ASSAYS' named entity 'OBSERVED' named entity 'GLYCOPROTEIN' named entity 'CORONAVIRUSES' named entity 'E2 GLYCOPROTEINS' named entity 'DESCRIBED' named entity 'ABSENT' named entity 'POLYMORPHISM' named entity 'MONOCLONAL ANTIBODY' named entity 'ANTIGEN BINDING' named entity 'DETERMINE' named entity 'CORONAVIRUSES' named entity 'POLYMORPHISM' named entity 'NON-NEUTRALIZING ANTIBODIES' covid:arg/b48dbc4c8d363fb48dbf7f6b7ca9c2591720e92b named entity 'antigenic' named entity 'glycoprotein' named entity 'virulent' named entity 'coronavirus' named entity 'polymorphism' named entity 'glycoproteins' named entity 'determinant' named entity 'extent' named entity 'MHV' named entity 'contrast' named entity 'strains' named entity 'termed' named entity 'binding assays' named entity 'MAb'

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