About: Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization

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About: Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization
Creator	Kakiuchi, Terutaka Kyuwa, Shigeru Matsuzawa, Akio Nakano, Hideki Tam, Carmen Gunn, Michael Williams, Lewis
Source	PMC
abstract	Secondary lymphoid organ chemokine (SLC) is expressed in high endothelial venules and in T cell zones of spleen and lymph nodes (LNs) and strongly attracts naive T cells. In mice homozygous for the paucity of lymph node T cell (plt) mutation, naive T cells fail to home to LNs or the lymphoid regions of spleen. Here we demonstrate that expression of SLC is undetectable in plt mice. In addition to the defect in T cell homing, we demonstrate that dendritic cells (DCs) fail to accumulate in spleen and LN T cell zones of plt mice. DC migration to LNs after contact sensitization is also substantially reduced. The physiologic significance of these abnormalities in plt mice is indicated by a markedly increased sensitivity to infection with murine hepatitis virus. The plt mutation maps to the SLC locus; however, the sequence of SLC introns and exons in plt mice is normal. These findings suggest that the abnormalities in plt mice are due to a genetic defect in the expression of SLC and that SLC mediates the entry of naive T cells and antigen-stimulated DCs into the T cell zones of secondary lymphoid organs.
has issue date	1999-02-01(xsd:dateTime)
bibo:pmid	9927507
has license	cc-by-nc-sa
sha1sum (hex)	b41e1c74739ae2195dc07a54fd9decaff5639b45
resource representing a document's title	Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization
has PubMed Central identifier	PMC2192914
has PubMed identifier	9927507
schema:publication	J Exp Med
resource representing a document's body	covid:b41e1c74739ae2195dc07a54fd9decaff5639b45#body_text
is schema:about of	named entity 'HIGH' named entity 'DENDRITIC CELLS' named entity 'DCS' named entity 'MURINE HEPATITIS VIRUS' named entity 'FINDINGS' named entity 'DEFECT' named entity 'SLC' named entity 'PLT' named entity 'NORMAL' named entity 'SENSITIZATION' named entity 'SECONDARY LYMPHOID ORGAN' named entity 'GENETIC DEFECT' named entity 'UNDETECTABLE' named entity 'SPLEEN' named entity 'NAIVE T CELLS' named entity 'MIGRATION' named entity 'STIMULATED' named entity 'ABNORMALITIES' named entity 'HERE' named entity 'defect' named entity 'lymphoid' named entity 'dendritic cells' named entity 'maps' named entity 'genetic defect' named entity 'LYMPHOCYTE HOMING' named entity 'MARKEDLY' named entity 'SECONDARY LYMPHOID ORGAN' named entity 'CELL LOCALIZATION' named entity 'VENULES' named entity 'LYMPH NODE' named entity 'LYMPH NODES' named entity 'MICE' named entity 'CHEMOKINE' named entity 'DENDRITIC CELL' named entity 'CHEMOKINE' named entity 'EXPRESSION' named entity 'HAVE' named entity 'LACKING' named entity 'MICE' named entity 'SIGNIFICANCE' named entity 'EXONS' named entity 'T CELL' named entity 'EXPRESSED' named entity 'LYMPHOID' named entity 'SECONDARY LYMPHOID ORGANS' named entity 'INCREASED SENSITIVITY TO INFECTION' named entity 'EXPRESSION' named entity 'MUTATION' named entity 'CONTACT' named entity 'ENTRY' named entity 'INTRONS' named entity 'ANTIGEN' named entity 'SEQUENCE' named entity 'DUE TO' named entity 'THESE' named entity 'ADDITION' named entity 'MEDIATES' named entity 'FAIL' named entity 'LNS' named entity 'PHYSIOLOGIC' named entity 'LOCUS' named entity 'SUGGEST' named entity 'HOMOZYGOUS' named entity 'REDUCED' named entity 'ENDOTHELIAL' named entity 'REGIONS' named entity 'MAPS' named entity 'HOME' named entity 'INDICATED' covid:arg/b41e1c74739ae2195dc07a54fd9decaff5639b45 named entity 'regions' named entity 'DCs' named entity 'plt' named entity 'mediates' named entity 'reduced' named entity 'mice' named entity 'spleen'

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