About: A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice

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About: A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice
Creator	Lima, M Ledwaba, Solanka Guerrant, Richard Henrique, Pedro Barry, Eileen Bolick, David Costa, Deiziane Kolling, Glynis Medeiros, Q Oriá, Reinaldo
Source	PMC
abstract	Vaccine studies for Shigella flexneri and enterotoxigenic Escherichia coli have been impaired by the lack of optimal animal models. We used two murine models to show that a S. flexneri 2a bivalent vaccine (CVD 1208S-122) expressing enterotoxigenic Escherichia coli colonization factor antigen-I (CFA/I) and the binding subunits A2 and B of heat labile-enterotoxin (LTb) is immunogenic and protects against weight loss and diarrhea. These findings document the immunogenicity and pre-clinical efficacy effects of CVD 1208S-122 vaccine and suggest that further work can help elucidate relevant immune responses and ultimately its clinical efficacy in humans.
has issue date	2020-03-27(xsd:dateTime)
bibo:doi	10.1038/s41541-020-0180-y
bibo:pmid	32257392
has license	cc-by
sha1sum (hex)	b3b8f977bbb48c268211654b69f9c82c6416dc02
schema:url	https://doi.org/10.1038/s41541-020-0180-y
resource representing a document's title	A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice
has PubMed Central identifier	PMC7101394
has PubMed identifier	32257392
schema:publication	NPJ Vaccines
resource representing a document's body	covid:b3b8f977bbb48c268211654b69f9c82c6416dc02#body_text
is schema:about of	named entity 'models' named entity 'humans' named entity 'These' named entity 'subunits' named entity 'weight loss' named entity 'Vaccine studies' named entity 'animal models' named entity 'CVD' named entity 'immune responses' named entity 'enterotoxigenic Escherichia coli' named entity 'vaccine' named entity 'murine models' named entity 'Weaned' named entity 'S. flexneri' named entity 'infection' named entity 'antibody' named entity 'S. flexneri' named entity 'ETEC' named entity 'Animal Experiments' named entity 'antibody' named entity 'S. flexneri' named entity 'mice' named entity 'infection' named entity 'antibiotic treatment' named entity 'DMEM' named entity 'serum samples' named entity 'CVD' named entity 'immunization' named entity 'ETEC' named entity 'infection' named entity 'diarrhea' named entity 'vaccination' named entity 'Shigella' named entity 'weight loss' named entity 'ETEC' named entity 'ETEC' named entity 'mice' named entity 'ETEC' named entity 'mice' named entity 'antibodies' named entity 'metronidazole' named entity 'enterotoxin' named entity 'ETEC' named entity 'vector' named entity 'vaccine' named entity 'antibody' named entity 'vaccines' named entity 'guaBA' named entity 'mice' named entity 'TMB' named entity 'prevent disease' named entity 'mice' named entity 'real-time quantitative PCR' named entity 'mice' named entity 'mice' named entity 'ETEC' named entity 'S. flexneri' named entity 'gentamicin' named entity 'ETEC' named entity 'diarrhea' named entity 'ETEC' named entity 'weight loss' named entity 'CVD' named entity 'shigellosis' named entity 'CVD' named entity 'Helsinki' named entity 'infection' named entity 'Shigella flexneri' named entity 'vector' named entity 'inoculation' named entity 'CVD' named entity 'mice'

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