About: Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men
Creator	Whistler, Toni Heim, Christine Lonergan, William Mletzko, Tanja Nater, Urs Vernon, Suzanne
source	Elsevier; Medline; PMC
abstract	Abstract We investigated peripheral blood mononuclear cell gene expression responses to acute psychosocial stress to identify molecular pathways relevant to the stress response. Blood samples were obtained from 10 healthy male subjects before, during and after (at 0, 30, and 60min) a standardized psychosocial laboratory stressor. Ribonucleic acid (RNA) was extracted and gene expression measured by hybridization to a 20,000-gene microarray. Gene Set Expression Comparisons (GSEC) using defined pathways were used for the analysis. Forty-nine pathways were significantly changed from baseline to immediately after the stressor (p <0.05), implicating cell cycle, cell signaling, adhesion and immune responses. The comparison between stress and recovery (measured 30min later) identified 36 pathways, several involving stress-responsive signaling cascades and cellular defense mechanisms. These results have relevance for understanding molecular mechanisms of the physiological stress response, and might be used to further study adverse health outcomes of psychosocial stress.
has issue date	2009-10-31(xsd:dateTime)
bibo:doi	10.1016/j.biopsycho.2009.06.009
bibo:pmid	19577611
has license	els-covid
sha1sum (hex)	b38102911b2a5bacb9145911983aa92e93445d06
schema:url	https://doi.org/10.1016/j.biopsycho.2009.06.009
resource representing a document's title	Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men
has PubMed Central identifier	PMC7116965
has PubMed identifier	19577611
schema:publication	Biological Psychology
resource representing a document's body	covid:b38102911b2a5bacb9145911983aa92e93445d06#body_text
is schema:about of	named entity 'PSYCHOSOCIAL STRESS' named entity 'GENE EXPRESSION' named entity 'molecular mechanisms' named entity 'GSEC' named entity 'gene' named entity 'Gene' named entity 'RIBONUCLEIC ACID' named entity 'HYBRIDIZATION' named entity 'HEALTH OUTCOMES' named entity 'STRESS RESPONSE' named entity 'GENE MICROARRAY' named entity 'IMMEDIATELY' named entity 'PSYCHOSOCIAL' named entity 'STRESSOR' named entity '0.05' named entity '2C CELL' named entity 'MIN' named entity 'GENE EXPRESSION' named entity 'TO IDENTIFY' named entity 'CELL SIGNALING' named entity 'USED' named entity 'STUDY' named entity 'DEFENSE MECHANISMS' named entity 'INVESTIGATED' named entity '28P' named entity 'MALE' named entity 'MOLECULAR' named entity 'OBTAINED' named entity '20%' named entity 'MEASURED' named entity 'RECOVERY' named entity 'MIGHT BE' named entity 'CELLULAR' named entity 'UNDERSTANDING' named entity 'BLOOD SAMPLES' covid:arg/b38102911b2a5bacb9145911983aa92e93445d06 named entity 'PATHWAYS' named entity 'HEALTHY' named entity 'CELL CYCLE' named entity 'RESPONSES' named entity 'FORTY-NINE' named entity 'PATHWAYS' named entity 'PSYCHOSOCIAL STRESS' named entity 'HAVE' named entity 'MECHANISMS' named entity 'INVOLVING' named entity 'SIGNALING CASCADES' named entity 'RELEVANT' named entity '30%' named entity 'RESPONSIVE' named entity 'SUBJECTS' named entity 'IMPACT' named entity 'ACUTE' named entity 'MEN' named entity 'PERIPHERAL BLOOD' named entity 'ANALYSIS' named entity 'IDENTIFIED' named entity 'LATER' named entity 'THESE' named entity 'CHANGED' named entity 'SET' named entity 'PHYSIOLOGICAL STRESS' named entity 'EXPRESSION' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELL' named entity 'GENE' named entity 'ADHESION' named entity 'DEFINED' named entity 'MOLECULAR PATHWAYS' named entity 'HEALTHY' named entity 'STRESS' named entity 'COMPARISON' named entity 'LABORATORY' named entity 'EXTRACTED' named entity 'ACUTE' named entity '30 MIN' named entity 'IMMUNE RESPONSES'

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