About: Bid-deficient fish delay grass carp reovirus (GCRV) replication and attenuate GCRV-triggered apoptosis

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About: Bid-deficient fish delay grass carp reovirus (GCRV) replication and attenuate GCRV-triggered apoptosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bid-deficient fish delay grass carp reovirus (GCRV) replication and attenuate GCRV-triggered apoptosis
Creator	Wang, Hao He, Libo Huang, Rong Li, Yongming Liao, Lanjie Luo, Lifei Wang, Yaping Zhu, Zuoyan
Source	PMC
abstract	Bid, BH3-interacting domain death agonist, is a pro-apoptotic BH3-only member of Bcl-2 family, playing an important role in apoptosis. In the study, Bid genes from grass carp (Ctenopharyngodon idellus) and rare minnow (Gobiocypris rarus), named CiBid and GrBid, were cloned and analyzed. Bid was constitutively expressed in all examined tissues of grass carp, but the expression level varied in different tissues. Following grass carp reovirus (GCRV) stimulation in vivo, Bid and apoptosis related genes Caspase-9 and Caspase-3 was up-regulated significantly at the late stage of infection. Moreover, we generated a Bid-deficient rare minnow (Bid(-/-)) to investigate the possible role of Bid in GCRV-triggered apoptosis. We found that the survival time of Bid(-/-) rare minnow after GCRV infection was extended when compared with wild-type fish, the relative copy number of GCRV in Bid(-/-) rare minnow was lower than that in wild-type fish, and the expression level of Caspase-9 and Caspase-3 in Bid(-/-) rare minnow were significantly lower than that in the wild-type fish. Collectively, the current data revealed the important role of Bid during virus-induced apoptosis in teleost fish. Our study would provide new insight into understanding the GCRV induced apoptosis and may provide a target gene for virus-resistant breeding in grass carp.
has issue date	2017-07-22(xsd:dateTime)
bibo:doi	10.18632/oncotarget.19460
bibo:pmid	29100321
has license	cc-by
sha1sum (hex)	b2d3a11928e26fbdd71764c358950fca41199fe5
schema:url	https://doi.org/10.18632/oncotarget.19460
resource representing a document's title	Bid-deficient fish delay grass carp reovirus (GCRV) replication and attenuate GCRV-triggered apoptosis
has PubMed Central identifier	PMC5652715
has PubMed identifier	29100321
schema:publication	Oncotarget
resource representing a document's body	covid:b2d3a11928e26fbdd71764c358950fca41199fe5#body_text
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