About: Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus
Creator	Guo, Baoqing Yang, Han-Chun Henningson, Jamie Lager, Kelly Miller, Laura Brockmeier, Susan Faaberg, Kay Kehrli, Marcus Nicholson, Tracy Kappes, Matthew Schlink, Sarah
Source	Elsevier; Medline; PMC
abstract	The pathogenesis of Type 2 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in 10-week old swine in the United States was investigated. rJXwn06, rescued from an infectious clone of Chinese HP-PRRSV, replicated in swine with at least 100-fold increased kinetics over U.S. strain VR-2332. rJXwn06 caused significant weight loss, exacerbated disease due to bacterial sepsis and more severe histopathological lung lesions in pigs exposed to HP-PRRSV than to those infected with VR-2332. Novel findings include identification of bacterial species present, the degree of thymic atrophy seen, and the inclusion of contact animals that highlighted the ability of HP-PRRSV to rapidly transmit between animals. Furthermore, comprehensive detailed cytokine analysis of serum, bronchoalveolar lavage fluid, and tracheobronchial lymph node tissue homogenate revealed a striking elevation in levels of cytokines associated with both innate and adaptive immunity in HP-PRRSV infected swine, and showed that contact swine differed in the degree of cytokine response.
has issue date	2013-01-20(xsd:dateTime)
bibo:doi	10.1016/j.virol.2012.09.013
bibo:pmid	23079105
has license	no-cc
sha1sum (hex)	b1c58671fac55ec315def856f0a171cadd52a892
schema:url	https://doi.org/10.1016/j.virol.2012.09.013
resource representing a document's title	Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus
has PubMed Central identifier	PMC7111980
has PubMed identifier	23079105
schema:publication	Virology
resource representing a document's body	covid:b1c58671fac55ec315def856f0a171cadd52a892#body_text
is schema:about of	named entity 'porcine reproductive and respiratory syndrome virus' named entity 'infection' named entity 'United States' named entity 'agar plate' named entity 'hematoxylin and eosin' named entity 'Type 2' named entity 'inoculum' named entity 'IL-4' named entity 'IL-2' named entity 'histopathologic examination' named entity 'Laos' named entity 'Group 3' named entity 'lung' named entity 'Cary, NC' named entity 'IL-2' named entity 'Group 3' named entity 'innate immunity' named entity 'BALF' named entity 'clinical disease' named entity 'IL-12' named entity 'sheep' named entity 'ileum' named entity 'TNFa' named entity 'serum' named entity 'deionized water' named entity 'genetics' named entity 'biological activity' named entity 'environmental conditions' named entity 'pathology' named entity '16S rRNA gene' named entity 'virus' named entity 'titer' named entity 'Chantilly, VA' named entity 'weight loss' named entity 'interstitial pneumonia' named entity 'mortality rates' named entity 'denaturation' named entity 'North American' named entity 'IL-8' named entity 'viral strain' named entity 'Tissues' named entity 'genetics' named entity 'IFNa' named entity 'Halbur' named entity 'inflammatory cytokine' named entity 'BALF' named entity 'virus isolation' named entity 'optical density' named entity 'Lymphadenopathy' named entity 'fetal bovine serum' named entity 'anorexic' named entity 'co-infection' named entity 'BALF' named entity 'primer' named entity 'IL-1' named entity 'cytokine' named entity 'infection' named entity 'pathology' named entity 'Faaberg' named entity 'toll-like receptor' named entity 'genome' named entity 'U.S. Department of Agriculture' named entity 'immune response' named entity 'upper respiratory tract' named entity 'BALF' named entity 'IL-8' named entity 'IFNg' named entity 'Arcanobacterium pyogenes' named entity 'secretion' named entity 'serum' named entity 'SAS Institute'

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