About: A host-protein signature is superior to other biomarkers for differentiating between bacterial and viral disease in patients with respiratory infection and fever without source: a prospective observational study

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About: A host-protein signature is superior to other biomarkers for differentiating between bacterial and viral disease in patients with respiratory infection and fever without source: a prospective observational study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A host-protein signature is superior to other biomarkers for differentiating between bacterial and viral disease in patients with respiratory infection and fever without source: a prospective observational study
Creator	Boico, Olga Cohen, Asi Eden, Eran Etshtein, Liat Friedman, Tom Klein, Adi Kronenfeld, Gali Navon, Roy Oved, Kfir Paz, Meital Srugo, Isaac Chistyakov, Irina Ashkenazi, Shai Ashkenazi-Hoffnung, Liat Scheuerman, Oded Gottlieb, Tanya
Source	Medline; PMC
abstract	Bacterial and viral infections often present with similar symptoms. Etiologic misdiagnosis can alter the trajectory of patient care, including antibiotic overuse. A host-protein signature comprising tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10 (IP-10), and C-reactive protein (CRP) was validated recently for differentiating bacterial from viral disease. However, a focused head-to-head comparison of its diagnostic performance against other biomarker candidates for this indication was lacking in patients with respiratory infection and fever without source. We compared the signature to other biomarkers and prediction rules using specimens collected prospectively at two secondary medical centers from children and adults. Inclusion criteria included fever > 37.5 °C, symptom duration ≤ 12 days, and presentation with respiratory infection or fever without source. Comparator method was based on expert panel adjudication. Signature and biomarker cutoffs and prediction rules were predefined. Of 493 potentially eligible patients, 314 were assigned unanimous expert panel diagnosis and also had sufficient specimen volume. The resulting cohort comprised 175 (56%) viral and 139 (44%) bacterial infections. Signature sensitivity 93.5% (95% CI 89.1–97.9%), specificity 94.3% (95% CI 90.7–98.0%), or both were significantly higher (all p values < 0.01) than for CRP, procalcitonin, interleukin-6, human neutrophil lipocalin, white blood cell count, absolute neutrophil count, and prediction rules. Signature identified as viral 50/57 viral patients prescribed antibiotics, suggesting potential to reduce antibiotic overuse by 88%. The host-protein signature demonstrated superior diagnostic performance in differentiating viral from bacterial respiratory infections and fever without source. Future utility studies are warranted to validate potential to reduce antibiotic overuse. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10096-018-3261-3) contains supplementary material, which is available to authorized users.
has issue date	2018-04-26(xsd:dateTime)
bibo:doi	10.1007/s10096-018-3261-3
bibo:pmid	29700762
has license	cc-by
sha1sum (hex)	b1bc4e62b880ab407cb7af2514847a38f76df2c7
schema:url	https://doi.org/10.1007/s10096-018-3261-3
resource representing a document's title	A host-protein signature is superior to other biomarkers for differentiating between bacterial and viral disease in patients with respiratory infection and fever without source: a prospective observational study
has PubMed Central identifier	PMC6015097
has PubMed identifier	29700762
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:b1bc4e62b880ab407cb7af2514847a38f76df2c7#body_text
is schema:about of	named entity 'volume' named entity 'candidates' named entity 'necrosis' named entity 'biomarker' named entity 'sensitivity' named entity 'overuse' named entity 'DIFFERENTIATING' named entity 'SUPERIOR' named entity 'PROSPECTIVE OBSERVATIONAL STUDY' named entity 'INCLUSION CRITERIA' named entity 'HUMAN' named entity 'PRESENT' named entity '2856' named entity 'RULES' named entity 'SUPERIOR' named entity 'C-REACTIVE PROTEIN' named entity 'ALTER' named entity 'ASSIGNED' named entity '10%' named entity 'COMPARISON' named entity 'MEDICAL CENTERS' named entity 'SECONDARY' named entity 'VALIDATED' named entity 'INTERFERON GAMMA' named entity 'BIOMARKERS' named entity 'VIRAL DISEASE' named entity '50%' named entity 'BASED' named entity 'ADULTS' named entity 'USING' named entity 'ABSOLUTE NEUTROPHIL COUNT' named entity '37.5' named entity 'BIOMARKER' named entity 'PATIENT CARE' named entity 'RESULTING' named entity 'COLLECTED' named entity 'PREDICTION' named entity 'NEUTROPHIL' named entity 'VIRAL' named entity 'COHORT' named entity 'HIGHER' named entity 'PANEL' named entity 'CHILDREN' named entity 'PRESENTATION' named entity 'ADJUDICATION' named entity '139' named entity 'DIFFERENTIATING' named entity 'INCLUDING' named entity 'HOST' named entity 'LIPOCALIN' named entity 'PERFORMANCE' named entity 'COMPARATOR' named entity 'BACTERIAL INFECTIONS' named entity 'SUFFICIENT' named entity 'SOURCE' named entity 'OVERUSE' named entity 'PROTEIN' named entity 'FEVER' named entity 'SIMILAR' named entity 'RESPIRATORY INFECTIONS' named entity 'CRP' named entity 'FEVER' named entity 'PATIENTS' named entity 'ANTIBIOTICS' named entity 'VIRAL INFECTIONS' named entity 'STUDIES'

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