About: Cytokine Activation Patterns and Biomarkers Are Influenced by Microorganisms in Community-Acquired Pneumonia

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About: Cytokine Activation Patterns and Biomarkers Are Influenced by Microorganisms in Community-Acquired Pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cytokine Activation Patterns and Biomarkers Are Influenced by Microorganisms in Community-Acquired Pneumonia
Creator	Menéndez, Rosario Torres, Antoni Polverino, Eva Reyes, Soledad Cillóniz, Catia Henricks, Kimberly Ginés Córdoba, Juan Martínez, Raquel Montull, Beatriz Sahuquillo-Arce, Miguel
source	Elsevier; Medline; PMC
abstract	Background The inflammatory response in community-acquired pneumonia (CAP) depends on the host and on the challenge of the causal microorganism. Here, we analyze the patterns of inflammatory cytokines, procalcitonin (PCT), and C-reactive protein (CRP) in order to determine their diagnostic value. Methods This was a prospective study of 658 patients admitted with CAP. PCT and CRP were analyzed by immunoluminometric and immunoturbidimetric assays. Cytokines (tumor necrosis factor-α [TNF-α], IL-1β, IL-6, IL-8, and IL-10) were measured using enzyme immunoassay. Results The lowest medians of CRP, PCT, TNF-α, and IL-6 were found in CAP of unknown cause, and the highest were found in patients with positive blood cultures. Different cytokine profiles and biomarkers were found depending on cause: atypical bacteria (lower PCT and IL-6), viruses (lower PCT and higher IL-10), Enterobacteriaceae (higher IL-8), Streptococcus pneumoniae (high PCT), and Legionella pneumophila (higher CRP and TNF-α). PCT ≥ 0.36 mg/dL to predict positive blood cultures showed sensitivity of 85%, specificity of 42%, and negative predictive value (NPV) of 98%, whereas a cutoff of ≤ 0.5 mg/dL to predict viruses or atypicals vs bacteria showed sensitivity of 89%/81%, specificity of 68%/68%, positive predictive value of 12%/22%, and NPV of 99%/97%. In a multivariate Euclidean distance model, the lowest inflammatory expression was found in unknown cause and the highest was found in L pneumophila, S pneumoniae, and Enterobacteriaceae. Atypical bacteria exhibit an inflammatory pattern closer to that of viruses. Conclusions Different inflammatory patterns elicited by different microorganisms may provide a useful tool for diagnosis. Recognizing these patterns provides additional information that may facilitate a broader understanding of host inflammatory response to microorganisms.
has issue date	2012-06-30(xsd:dateTime)
bibo:doi	10.1378/chest.11-1446
bibo:pmid	22194589
has license	els-covid
sha1sum (hex)	b10f60b3b2acf3df12afc5e428c284b15a53f9e8
schema:url	https://doi.org/10.1378/chest.11-1446
resource representing a document's title	Cytokine Activation Patterns and Biomarkers Are Influenced by Microorganisms in Community-Acquired Pneumonia
has PubMed Central identifier	PMC7094498
has PubMed identifier	22194589
schema:publication	Chest
resource representing a document's body	covid:b10f60b3b2acf3df12afc5e428c284b15a53f9e8#body_text
is schema:about of	named entity 'blood cultures' named entity 'TNF-a' named entity 'CAP' named entity 'predict' named entity 'predict' named entity 'Cytokine' named entity 'Pneumonia' named entity 'SENSITIVITY' named entity 'C-REACTIVE PROTEIN' named entity 'NPV' named entity 'EUCLIDEAN DISTANCE' named entity 'USING' named entity 'VALUE' named entity 'IL-1' named entity 'FOR DIAGNOSIS' covid:arg/b10f60b3b2acf3df12afc5e428c284b15a53f9e8 named entity 'MODEL' named entity 'LOWEST' named entity 'CAP' named entity 'PCT' named entity 'WAS A' named entity 'RESPONSE' named entity 'CITY' named entity 'PATTERNS' named entity '0.5' named entity 'BLOOD CULTURES' named entity '658' named entity 'MICROORGANISMS' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'CAUSE' named entity 'CYTOKINE ' named entity 'CUTOFF' named entity 'CRP' named entity 'CYTOKINE ACTIVATION' named entity 'UNDERSTANDING' named entity 'METHODS' named entity 'MICROORGANISMS' named entity 'BIOMARKERS' named entity 'MEASURED' named entity 'DIAGNOSTIC' named entity 'ATYPICAL' named entity 'PATTERN' named entity 'HIGHER' named entity 'INFLAMMATORY' named entity 'CHALLENGE' named entity 'DETERMINE' named entity 'PROVIDE' named entity 'RESPONSE TO' named entity 'TOOL' named entity 'IL-8' named entity 'ELICITED BY' named entity 'PROTEIN ' named entity 'PNEUMOPHILA' named entity 'USEFUL' named entity 'NEGATIVE PREDICTIVE VALUE' named entity 'ADMITTED' named entity 'EXPRESSION' named entity 'PREDICT' named entity 'IL-6' named entity 'MICROORGANISM' named entity 'MG%' named entity 'NECROSIS FACTOR' named entity 'UNKNOWN CAUSE' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'THESE' named entity 'VIRUSES' named entity '10%' named entity 'FOUND' named entity 'HIGHEST' named entity 'DIFFERENT' named entity 'PATIENTS' named entity 'TNF-A'

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