About: A Gene Encoding Sialic-Acid-Specific 9-O-Acetylesterase Found in Human Adult Testis

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About: A Gene Encoding Sialic-Acid-Specific 9-O-Acetylesterase Found in Human Adult Testis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A Gene Encoding Sialic-Acid-Specific 9-O-Acetylesterase Found in Human Adult Testis
Creator	Li, Jianming Zhu, Hui Cheng, Lijun Sha, Jiahao Xu, Ming Yin, Lanlan Zhou, Zuoming Zhu, Hu Chan, Hsiao
source	PMC
abstract	Using differential display RT-PCR, we identified a gene of 2750 bp from human adult testis, named H-Lse, which encoded a putative protein of 523 amino acids and molecular weight of 58 kd with structural characteristics similar to that of mouse lysosome sialic-acid-specific 9-O-acetylesterase. Northern blot analysis showed a widespread distribution of H-Lse in various human tissues with high expression in the testis, prostate, and colon. In situ hybridization results showed that while H-Lse was not detected in embryonic testis, positive signals were found in spermatocytes but not spermatogonia in adult testis of human. The subcellular localization of H-Lse was visualized by green fluorescent protein (GFP) fused to the amino terminus of H-Lse, showing compartmentalization of H-Lse in large dense-core vesicles, presumably lysosomes, in the cytoplasm. The developmentally regulated and spermatogenic stage-specific expression of H-Lse suggests its possible involvement in the development of the testis and/or differentiation of germ cells.
has issue date	2004-07-29(xsd:dateTime)
bibo:doi	10.1155/s1110724304307084
bibo:pmid	15292578
has license	no-cc
sha1sum (hex)	b022e6ee1e7b9a0a822b1255c2fa12f81ddc52fd
schema:url	https://doi.org/10.1155/s1110724304307084
resource representing a document's title	A Gene Encoding Sialic-Acid-Specific 9-O-Acetylesterase Found in Human Adult Testis
has PubMed Central identifier	PMC551583
has PubMed identifier	15292578
schema:publication	J Biomed Biotechnol
resource representing a document's body	covid:b022e6ee1e7b9a0a822b1255c2fa12f81ddc52fd#body_text
is schema:about of	named entity 'ENCODING' named entity 'spermatocytes' named entity 'high' named entity 'identified' named entity 'prostate' named entity 'signals' named entity 'lysosome' named entity 'Gene' named entity 'STRUCTURAL' named entity 'BUT' named entity 'SPECIFIC' named entity 'SIMILAR' named entity 'A GENE' named entity 'IDENTIFIED' named entity 'EMBRYONIC TESTIS' named entity 'RT-PCR' named entity 'DIFFERENTIATION' named entity 'VISUALIZED' named entity 'LYSOSOMES' named entity 'GREEN FLUORESCENT PROTEIN' named entity 'WIDESPREAD' named entity 'INVOLVEMENT' named entity 'POSITIVE' named entity 'COLON' named entity '523' named entity 'USING' named entity 'DISTRIBUTION' named entity 'DENSE' named entity 'NOT DETECTED' named entity 'MOLECULAR WEIGHT' named entity 'DIFFERENTIAL DISPLAY' named entity 'SPERMATOGENIC' named entity 'STAGE' named entity 'RESULTS' named entity 'REGULATED' named entity 'PROSTATE' named entity 'HUMAN' named entity 'POSSIBLE' named entity 'LARGE' named entity 'ENCODED' named entity 'FOUND' named entity 'ACETYLESTERASE' named entity 'LYSOSOME' named entity 'HUMAN ADULT' named entity 'FUSED TO' named entity 'FOUND' named entity 'NORTHERN BLOT ANALYSIS' named entity 'AMINO' named entity 'ITS' named entity 'AMINO ACIDS' named entity 'SUBCELLULAR LOCALIZATION' covid:arg/b022e6ee1e7b9a0a822b1255c2fa12f81ddc52fd named entity 'EXPRESSION' named entity 'NAMED' named entity 'GERM CELLS' named entity 'ADULT TESTIS' named entity 'MOUSE' named entity 'ADULT TESTIS' named entity 'HUMAN ADULT' named entity 'SPECIFIC' named entity 'VESICLES' named entity 'SPERMATOGONIA' named entity 'ACETYLESTERASE' named entity 'TESTIS' named entity 'HUMAN TISSUES' named entity 'TERMINUS' named entity 'CORE' named entity 'CHARACTERISTICS' named entity 'HIGH EXPRESSION' named entity 'VARIOUS' named entity 'IN SITU HYBRIDIZATION' named entity 'SIGNALS' named entity 'SPERMATOCYTES'

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