About: Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome
Creator	Peiris, Malik Liu, Wei Huang, Fang-Ping Khoo, Ui-Soon Lai, Sik-To Chu, Chung-Ming Song, You-Qiang Chan, Vera Chan, Jane Chan, Kelvin Chan, Li-Chong Cheung, Annie Kong, Hong Leung, G Lin, Steve Tam, Paul Wong, Andrew Yam, Loretta Yip, Shea-Ping Chan, Eric Chow, Eudora Hospital, Margaret Ngan, Hextan Xu, M Sham, Pak Ching, Johannes Chung, P Hospital, United
Source	Medline; PMC
abstract	Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3 were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute respiratory syndrome (SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS-CoV infection was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (P=.0067; odds ratio [OR], 4.31 [95% confidence interval [CI], 1.37–13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10–0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS.
has issue date	2007-07-15(xsd:dateTime)
bibo:doi	10.1086/518892
bibo:pmid	17570115
has license	no-cc
sha1sum (hex)	b01b26db05a39f6f955d25d1af8f899ab4b387cb
schema:url	https://doi.org/10.1086/518892
resource representing a document's title	Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome
has PubMed Central identifier	PMC7202406
has PubMed identifier	17570115
schema:publication	J Infect Dis
resource representing a document's body	covid:b01b26db05a39f6f955d25d1af8f899ab4b387cb#body_text
is schema:about of	named entity 'conducted' named entity 'health care worker' named entity 'genotyping' named entity 'ICAM3' named entity 'L-SIGN' named entity 'immunopathogenesis' named entity 'LDH' named entity 'SNP' named entity 'ICAM3' named entity 'allele frequency' named entity 'polymorphism' named entity 'biochemical' named entity 'ACE2' named entity 'infection' named entity 'WBC' named entity '13.0' named entity 'polymorphism' named entity 'ICAM3' named entity 'HLA-B' named entity 'potassium' named entity 'ICU' named entity 'homozygous' named entity 'FCER2' named entity 'infection' named entity 'DC-SIGN' named entity 'ICAM3' named entity 'ICU' named entity 'odds ratio' named entity 'ICAM3' named entity 'SARS-CoV' named entity 'statistical analysis' named entity 'LDH' named entity 'ICAM3' named entity 'SARS' named entity 'coronavirus' named entity 'leukocyte' named entity 'L-SIGN' named entity 'Hong Kong' named entity 'SNPs' named entity 'SNPs' named entity 'creatinine kinase' named entity 'asymptomatic' named entity 'glycine' named entity 'HIV-infected patients' named entity 'lymph node' named entity 'SARS' named entity 'conformational change' named entity 'ICAM3' named entity 'proinflammatory cytokines' named entity 'L-SIGN' named entity 'hematological' named entity 'control subjects' named entity 'SARS' named entity 'DCs'

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