Our data revealed that the mRNA expression levels of three ribosomal RNAs ( RDN5 . 8 , RDN18 , and RDN25 ) remained stable in response to fluconazole , while PGK1 , UBC7 , and UBC13 mRNAs showed only approximately 2 . 9 - , 3 . 0 - , and 2 . 5 - fold induction by azole , respectively .