About: Metagenomic analysis of a sample from a patient with respiratory tract infection reveals the presence of a γ-papillomavirus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Metagenomic analysis of a sample from a patient with respiratory tract infection reveals the presence of a γ-papillomavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Metagenomic analysis of a sample from a patient with respiratory tract infection reveals the presence of a γ-papillomavirus
Creator	Canuti, Marta Deijs, Martin Goossens, Herman Ieven, Margareta Lammens, Christine Zoll, Jan Jebbink, Maarten Brugman, Curt Holwerda, Melle Loens, Katherine Verheij, Theo De Vries, Michel Dutilh, Bas Farsani, Seyed Sullivan, Chris Van Der Hoek, Lia Van Vugt, Saskia
Source	Medline; PMC
abstract	Previously unknown or unexpected pathogens may be responsible for that proportion of respiratory diseases in which a causative agent cannot be identified. The application of broad-spectrum, sequence independent virus discovery techniques may be useful to reduce this proportion and widen our knowledge about respiratory pathogens. Thanks to the availability of high-throughput sequencing (HTS) technology, it became today possible to detect viruses which are present at a very low load, but the clinical relevance of those viruses must be investigated. In this study we used VIDISCA-454, a restriction enzyme based virus discovery method that utilizes Roche 454 HTS system, on a nasal swab collected from a subject with respiratory complaints. A γ-papillomavirus was detected (complete genome: 7142 bp) and its role in disease was investigated. Respiratory samples collected both during the acute phase of the illness and 2 weeks after full recovery contained the virus. The patient presented antibodies directed against the virus but there was no difference between IgG levels in blood samples collected during the acute phase and 2 weeks after full recovery. We therefore concluded that the detected γ-papillomavirus is unlikely to be the causative agent of the respiratory complaints and its presence in the nose of the patient is not related to the disease. Although HTS based virus discovery techniques proved their great potential as a tool to clarify the etiology of some infectious diseases, the obtained information must be subjected to cautious interpretations. This study underlines the crucial importance of performing careful investigations on viruses identified when applying sensitive virus discovery techniques, since the mere identification of a virus and its presence in a clinical sample are not satisfactory proofs to establish a causative link with a disease.
has issue date	2014-07-08(xsd:dateTime)
bibo:doi	10.3389/fmicb.2014.00347
bibo:pmid	25071755
has license	cc-by
sha1sum (hex)	af6cc29d9bc7f9d84ded3d7ad30509a945e425d3
schema:url	https://doi.org/10.3389/fmicb.2014.00347
resource representing a document's title	Metagenomic analysis of a sample from a patient with respiratory tract infection reveals the presence of a γ-papillomavirus
has PubMed Central identifier	PMC4086198
has PubMed identifier	25071755
schema:publication	Front Microbiol
resource representing a document's body	covid:af6cc29d9bc7f9d84ded3d7ad30509a945e425d3#body_text
is schema:about of	named entity 'PAPILLOMAVIRUS' named entity 'PATIENT' named entity 'ANALYSIS' named entity 'RESPIRATORY TRACT INFECTION' named entity 'REVEALS' named entity 'SAMPLE' named entity 'PRESENCE OF' named entity 'staining' named entity 'Primary Care Network' named entity 'high-throughput sequencing' named entity 'HPV' named entity 'HPVs' named entity 'nostril' named entity 'SDS-page' named entity 'nucleic acids' named entity 'IPTG' named entity 'cloned' named entity 'spp' named entity 'RNA viruses' named entity 'virus' named entity 'surgical treatments' named entity 'HTS' named entity 'headache' named entity 'diagnostic assays' named entity 'HTS' named entity 'etiology' named entity 'GenBank' named entity 'metapneumovirus' named entity 'real time PCR' named entity 'index patient' named entity 'index patient' named entity 'GenBank' named entity 'HPVs' named entity 'skimmed milk' named entity 'viruses' named entity 'Papillomaviruses' named entity 'SDS-Page' named entity 'respiratory diseases' named entity 'gene' named entity 'cervical cancer' named entity 'cloned' named entity 'virus' named entity 'pathogens' named entity 'capsid protein' named entity 'fever' named entity 'recurrent respiratory papillomatosis' named entity 'molecular biology' named entity 'Kurose' named entity 'animal reservoir' named entity 'mucous membranes' named entity 'causative agent' named entity 'phlegm' named entity 'restriction enzyme' named entity 'RRP' named entity 'virus' named entity 'viruses' named entity 'skin lesions' named entity 'respiratory disease' named entity 'acute phase' named entity 'virus' named entity 'virus' named entity 'HPVs' named entity 'double stranded DNA' named entity 'nostril' named entity 'causative agent'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software