About: Discovery and Partial Genomic Characterisation of a Novel Nidovirus Associated with Respiratory Disease in Wild Shingleback Lizards (Tiliqua rugosa)

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Discovery and Partial Genomic Characterisation of a Novel Nidovirus Associated with Respiratory Disease in Wild Shingleback Lizards (Tiliqua rugosa) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Discovery and Partial Genomic Characterisation of a Novel Nidovirus Associated with Respiratory Disease in Wild Shingleback Lizards (Tiliqua rugosa)
Creator	Jackson, Bethany Jackson, Carol Warren, Kristin O'dea, Mark
Source	Medline; PMC
abstract	A respiratory disease syndrome has been observed in large numbers of wild shingleback lizards (Tiliqua rugosa) admitted to wildlife care facilities in the Perth metropolitan region of Western Australia. Mortality rates are reportedly high without supportive treatment and care. Here we used next generation sequencing techniques to screen affected and unaffected individuals admitted to Kanyana Wildlife Rehabilitation Centre in Perth between April and December 2015, with the resultant discovery of a novel nidovirus significantly associated with cases of respiratory disease according to a case definition based on clinical signs. Interestingly this virus was also found in 12% of apparently healthy individuals, which may reflect testing during the incubation period or a carrier status, or it may be that this agent is not causative in the disease process. This is the first report of a nidovirus in lizards globally. In addition to detection of this virus, characterisation of a 23,832 nt segment of the viral genome revealed the presence of characteristic nidoviral genomic elements providing phylogenetic support for the inclusion of this virus in a novel genus alongside Ball Python nidovirus, within the Torovirinae sub-family of the Coronaviridae. This study highlights the importance of next generation sequencing technologies to detect and describe emerging infectious diseases in wildlife species, as well as the importance of rehabilitation centres to enhance early detection mechanisms through passive and targeted health surveillance. Further development of diagnostic tools from these findings will aid in detection and control of this agent across Australia, and potentially in wild lizard populations globally.
has issue date	2016-11-09(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0165209
bibo:pmid	27828982
has license	cc-by
sha1sum (hex)	aee43bea8ff949773e7d22ebbfd6304c20c2a76d
schema:url	https://doi.org/10.1371/journal.pone.0165209
resource representing a document's title	Discovery and Partial Genomic Characterisation of a Novel Nidovirus Associated with Respiratory Disease in Wild Shingleback Lizards (Tiliqua rugosa)
has PubMed Central identifier	PMC5102451
has PubMed identifier	27828982
schema:publication	PLoS One
resource representing a document's body	covid:aee43bea8ff949773e7d22ebbfd6304c20c2a76d#body_text
is schema:about of	named entity 'PARTIAL' named entity 'WILD' named entity 'lizards' named entity 'SHINGLEBACK' named entity 'RUGOSA' named entity 'ASSOCIATED WITH' named entity 'LIZARDS' named entity 'RESPIRATORY DISEASE' named entity 'GENOMIC' named entity 'NUMBERS' named entity 'NOVEL' named entity 'SHINGLEBACK' named entity 'RUGOSA' named entity 'DISCOVERY' named entity 'WILD' named entity 'RESPIRATORY DISEASE' named entity 'LARGE' named entity 'LIZARDS' named entity 'OBSERVED' named entity 'SYNDROME' named entity 'lizards' named entity 'Tiliqua rugosa' named entity 'Lizards' named entity 'Shingleback' named entity 'Nidovirus' named entity 'Tiliqua rugosa' named entity 'reptile' named entity 'nidovirus' named entity 'bootstrap method' named entity 'Australia' named entity 'RT-PCR' named entity 'Tiliqua' named entity 'amino acid sequence' named entity 'brushtail possums' named entity 'viruses' named entity 'risk factors' named entity 'Ball python' named entity 'Illumina' named entity 'quarantine' named entity 'Metronidazole' named entity 'infectious disease' named entity 'genus' named entity 'lizards' named entity 'ribosomal frameshift' named entity 'false negatives' named entity 'haematological' named entity 'reptiles' named entity 'respiratory diseases' named entity 'wildlife veterinarian' named entity 'RT-PCR' named entity 'Viruses' named entity 'Genomic analysis' named entity 'pathogen' named entity 'BLASTn' named entity 'inappetence' named entity 'contig' named entity 'microbial' named entity 'amino acid' named entity 'flu' named entity 'RdRp' named entity 'herpesviruses' named entity 'immunohistochemistry' named entity 'zoonotic pathogens' named entity 'Wildlife Rehabilitation' named entity 'ORFs' named entity 'protease' named entity 'Phyre2' named entity 'coding region' named entity 'distilled water' named entity 'respiratory disease' named entity 'clade' named entity 'translocation' named entity 'sympatric' named entity 'transmembrane region' named entity 'protein' named entity 'respiratory disease' named entity 'lizards' named entity 'reptile'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software