About: Interactome of SARS-CoV-2 / nCoV19 modulated host proteins with computationally predicted PPIs

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About: Interactome of SARS-CoV-2 / nCoV19 modulated host proteins with computationally predicted PPIs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interactome of SARS-CoV-2 / nCoV19 modulated host proteins with computationally predicted PPIs
Creator	Ganapathiraju, Madhavi Karunakaran, Kalyani Balakrishnan, N
Source	Medline; PMC
abstract	World over, people are looking for solutions to tackle the pandemic coronavirus disease (COVID-19) caused by the virus SARS-CoV-2/nCoV-19. Notable contributions in biomedical field have been characterizing viral genomes, host transcriptomes and proteomes, repurposable drugs and vaccines. In one such study, 332 human proteins targeted by nCoV19 were identified. We expanded this set of host proteins by constructing their protein interactome, including in it not only the known protein-protein interactions (PPIs) but also novel, hitherto unknown PPIs predicted with our High-precision Protein-Protein Interaction Prediction (HiPPIP) model that was shown to be highly accurate. In fact, one of the earliest discoveries made possible by HiPPIP is related to activation of immunity upon viral infection. We found that several interactors of the host proteins are differentially expressed upon viral infection, are related to highly relevant pathways, and that the novel interaction of NUP98 with CHMP5 may activate an antiviral mechanism leading to disruption of viral budding. We are making the interactions available as downloadable files to facilitate future systems biology studies and also on a web-server at http://hagrid.dbmi.pitt.edu/corona that allows not only keyword search but also queries such as “PPIs where one protein is associated with ‘virus’ and the interactors with ‘pulmonary’”.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.21203/rs.3.rs-28592/v1
bibo:pmid	32702714
has license	cc-by
sha1sum (hex)	aee3a47fa1a1968a63cc9631b387db7656876f65
schema:url	https://doi.org/10.21203/rs.3.rs-28592/v1
resource representing a document's title	Interactome of SARS-CoV-2 / nCoV19 modulated host proteins with computationally predicted PPIs
has PubMed Central identifier	PMC7336710
has PubMed identifier	32702714
schema:publication	Res Sq
resource representing a document's body	covid:aee3a47fa1a1968a63cc9631b387db7656876f65#body_text
is schema:about of	named entity 'computationally' named entity 'PREDICTED' named entity 'SARS-CoV-2' named entity 'modulated' named entity 'SARS-CoV-2' named entity 'PPIs' named entity 'SARS-CoV-2' named entity 'CHMP5' named entity 'ARDS' named entity 'ZFP36' named entity 'IFN' named entity 'coronaviridae' named entity 'gene expression' named entity 'infection' named entity 'middle east respiratory syndrome' named entity 'staurosporine' named entity 'interactome' named entity 'cilium' named entity 'statistically significant' named entity 'ANAPC4' named entity 'bradycardia' named entity 'infection' named entity 'host cell' named entity 'P-value' named entity 'viral budding' named entity 'DYNC1H1' named entity 'co-morbidities' named entity 'Co-IP' named entity 'endosomal transport' named entity 'interactome' named entity 'diabetes' named entity 'epithelial cells' named entity 'viral infection' named entity 'OASL' named entity 'hormone' named entity 'microarray' named entity 'Gene Ontology' named entity 'positive-sense single-stranded RNA' named entity 'homeostasis' named entity 'infection' named entity 'protein' named entity 'viral infection' named entity 'gene expression' named entity 'disease mechanisms' named entity 'viruses' named entity 'phase transition' named entity 'lungs' named entity 'signalling pathways' named entity 'Cytoscape' named entity 'interactome' named entity 'SARS coronavirus' named entity 'viral infections' named entity 'DCTN1' named entity 'cell entry' named entity 'CHMP5' named entity 'probability' named entity 'mitochondrion' named entity 'viral budding' named entity 'NINL' named entity 'atherosclerosis' named entity 'cardiovascular' named entity 'viral entry' named entity 'interferon' named entity 'aortic root' named entity 'infection' named entity 'respiratory syncytial viruses' named entity 'interactome' named entity 'phase transitions' named entity 'SARS-2' named entity 'ISG15' named entity 'protein-protein interaction' named entity 'viral proteins' named entity 'INHBA' named entity 'G2/M' named entity 'Biological Processes' named entity 'NEK9' named entity 'ATPase' named entity 'heart tissue' named entity 'cell line'

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