About: Clinical and immunologic studies in identical twins discordant for systemic lupus erythematosus

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About: Clinical and immunologic studies in identical twins discordant for systemic lupus erythematosus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical and immunologic studies in identical twins discordant for systemic lupus erythematosus
Creator	John, S Brunner, Carolyn Charlottesville, Virginia David, A Davis, Horwitz, Mary, K Shann, Sturgill, Benjamin
Source	Elsevier; Medline; PMC
abstract	Abstract Middle-aged female identical twins, one of whom had systemic lupus erythematosus (SLE), were evaluated for immunologic reactivity to previous antigenic challenges, including primary immunization with a foreign antigen, keyhole limpet hemocyanin (KLH). These two women had lived together for all of their 58 years and neither was receiving anti-inflammatory or immunosuppressive drugs at the time of these studies. Both twins demonstrated comparable 7S and 198 humoral antibody response to KLH, as well as similar viral antibody titers. However, the twin with SLE was anergic to common antigens, streptokinase-streptodornase, Trichophyton and Candida; furthermore delayed hypersensitivity to KLH did not develop after immunization. This observed discrepancy between humoral and cellular immunity in genetically similar subjects may be significant in the pathogenesis of SLE.
has issue date	1973-08-31(xsd:dateTime)
bibo:doi	10.1016/0002-9343(73)90176-9
bibo:pmid	4579077
has license	els-covid
sha1sum (hex)	aecbc613ebdab36753235197ffb4f35734b5ca63
schema:url	https://doi.org/10.1016/0002-9343%2873%2990176-9
resource representing a document's title	Clinical and immunologic studies in identical twins discordant for systemic lupus erythematosus
has PubMed Central identifier	PMC7119382
has PubMed identifier	4579077
schema:publication	The American Journal of Medicine
resource representing a document's body	covid:aecbc613ebdab36753235197ffb4f35734b5ca63#body_text
is schema:about of	named entity 'SLE' named entity 'antibody' named entity 'KLH' named entity 'twins' named entity 'immunization' named entity 'twin' named entity 'CLINICAL' named entity 'DRUGS' named entity 'IMMUNOLOGIC' named entity 'IDENTICAL TWINS' named entity 'SIGNIFICANT' named entity 'SLE' named entity 'DID' named entity 'STREPTOKINASE-STREPTODORNASE' named entity 'MAY BE' named entity 'RESPONSE TO' named entity 'COMMON' named entity 'ANTIGEN' named entity 'THEIR' named entity 'YEARS' named entity 'CANDIDA' named entity 'STUDIES' named entity 'NEITHER' named entity 'EVALUATED' named entity 'THESE' named entity 'PATHOGENESIS' named entity 'OBSERVED' named entity 'AGED' named entity 'MIDDLE' named entity 'PRIMARY IMMUNIZATION' named entity 'VIRAL ANTIBODY' named entity 'IMMUNIZATION' named entity 'DELAYED HYPERSENSITIVITY' named entity 'SUBJECTS' named entity 'IMMUNOLOGIC' named entity 'DISCORDANT' named entity 'SYSTEMIC LUPUS ERYTHEMATOSUS' named entity 'TIME' named entity 'STUDIES' named entity 'PREVIOUS' named entity 'KEYHOLE LIMPET HEMOCYANIN' named entity 'TWIN' named entity 'TWINS' named entity 'REACTIVITY' named entity 'FEMALE' named entity 'CELLULAR IMMUNITY' named entity 'CHALLENGES' named entity 'ANTIBODY RESPONSE' named entity 'TRICHOPHYTON' named entity 'KLH' named entity 'DISCREPANCY' named entity 'ANTIBODY TITERS' named entity 'INCLUDING' named entity '19S' named entity 'SYSTEMIC LUPUS ERYTHEMATOSUS' named entity 'SIMILAR' named entity 'DEMONSTRATED' named entity 'IMMUNOSUPPRESSIVE' named entity 'ONE OF' named entity 'RECEIVING' named entity 'WOMEN' named entity 'FOREIGN' named entity 'ANTI-INFLAMMATORY' named entity 'ANTIGENS' named entity 'IDENTICAL TWINS' covid:arg/aecbc613ebdab36753235197ffb4f35734b5ca63 named entity 'subjects' named entity 'lupus' named entity 'This' named entity 'studies' named entity 'SLE' named entity 'antibody' named entity 'KLH'

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