About: TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

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About: TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
Creator	Ding, Siyuan Wang, Xin Diamond, Michael Greenberg, Harry Sonnek, Naomi Whelan, Sean Mccune, Broc Liu, Zhuoming Florencia Gomez Castro, Maria Rothlauf, Paul Zang, Ruochen Zeng, Qiru Brulois, Kevin Ciorba, Matthew
Source	Medline; PMC
abstract	Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed in COVID-19 patients. However, it is unclear whether SARS-CoV-2 replicates in the human intestine and contributes to possible fecal-oral transmission. Here, we report productive infection of SARS-CoV-2 in ACE2(+) mature enterocytes in human small intestinal enteroids. Expression of two mucosa-specific serine proteases, TMPRSS2 and TMPRSS4, facilitated SARS-CoV-2 spike fusogenic activity and promoted virus entry into host cells. We also demonstrate that viruses released into the intestinal lumen were inactivated by simulated human colonic fluid, and infectious virus was not recovered from the stool specimens of COVID-19 patients. Our results highlight the intestine as a potential site of SARS-CoV-2 replication, which may contribute to local and systemic illness and overall disease progression.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1126/sciimmunol.abc3582
bibo:pmid	32404436
has license	cc-by
sha1sum (hex)	add20e4c4d7fe6295a51713218691727aa67c8a2
schema:url	https://doi.org/10.1126/sciimmunol.abc3582
resource representing a document's title	TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
has PubMed Central identifier	PMC7285829
has PubMed identifier	32404436
schema:publication	Sci Immunol
resource representing a document's body	covid:add20e4c4d7fe6295a51713218691727aa67c8a2#body_text
is schema:about of	named entity 'replicates' named entity 'activity' named entity 'SMALL INTESTINAL' named entity 'PRODUCTIVE' named entity 'HUMAN INTESTINE' named entity 'SARS-COV-2 REPLICATION' named entity 'Page' named entity 'proteases' named entity 'productive' named entity 'mature' named entity 'cells' named entity 'promoted' named entity 'patients' named entity 'replication' named entity 'intestine' named entity 'intestinal lumen' named entity 'SARS-CoV-2' named entity 'systemic illness' named entity 'small intestinal' named entity 'viruses' named entity 'immunology' named entity 'human intestine' named entity 'host cells' named entity 'COVID' named entity 'fusogenic' named entity 'TMPRSS2' named entity 'Gastrointestinal symptoms' named entity 'SARS-CoV-2' named entity 'serine proteases' named entity 'spike' named entity 'lung' named entity 'cognate' named entity 'fecal-oral route' named entity 'SARS-CoV-2' named entity 'Coronavirus disease 2019' named entity 'SARS-CoV-2' named entity 'surfactants' named entity 'membrane fusion' named entity 'TMPRSS2' named entity 'recombinant proteins' named entity 'viral RNA' named entity 'inflammatory bowel disease' named entity 'Ectopic expression' named entity 'salt' named entity 'wild-type' named entity 'protein' named entity 'morbidity' named entity 'trypsin inhibitor' named entity 'virus' named entity 'VSV' named entity 'SARS-CoV-2' named entity 'transduced' named entity 'ACE2' named entity 'Thermo Fisher' named entity 'M199' named entity 'syncytia' named entity 'receptor' named entity 'trypsin inhibitor' named entity 'GI tract' named entity 'duodenum' named entity 'SARS-CoV-2' named entity 'CD94' named entity 'plaque assay' named entity 'VSV' named entity 'camostat' named entity '2019-nCoV' named entity 'Cas9' named entity 'Staining'

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