About: SARS‐CoV‐2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: SARS‐CoV‐2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS‐CoV‐2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein
Creator	Yury, \| Correspondence, Siarhei Dabravolski, Dabravolski, Siarhei Kavalionak, Kazimirovich
Source	Medline; PMC; WHO
abstract	To investigate the evolutionary history of the current pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a total of 137 genomes of coronavirus strains with release dates between January 2019 and 25 March 2020, were analyzed. To investigate the potential intermediate host of the SARS‐CoV‐2, we analyzed spike glycoprotein sequences from different animals, with particular emphasis on bats. We performed phylogenetic analysis and structural reconstruction of the spike glycoproteins with subsequent alignment and comparison. Our phylogenetic results revealed that SARS‐CoV‐2 was more similar to the bats' betacoronavirus isolates: HKU5‐related from Pipistrellus abramus and HKU4‐related from Tylonycteris pachypus. We also identified a yak betacoronavirus strain, YAK/HY24/CH/2017, as the closest match in the comparison of the structural models of spike glycoproteins. Interestingly, a set of unique features has been described for this particular strain of the yak betacoronavirus. Therefore, our results suggest that the human SARS‐CoV‐2, responsible for the current outbreak of COVID‐19, could also come from yak as an intermediate host.
has issue date	2020-05-17(xsd:dateTime)
bibo:doi	10.1002/jmv.25976
bibo:pmid	32374452
has license	no-cc
sha1sum (hex)	ad94331f2faaa094d98785ce7ac548a3d4e6cb4b
schema:url	https://doi.org/10.1002/jmv.25976
resource representing a document's title	SARS‐CoV‐2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein
has PubMed Central identifier	PMC7267556
has PubMed identifier	32374452
schema:publication	J Med Virol
resource representing a document's body	covid:ad94331f2faaa094d98785ce7ac548a3d4e6cb4b#body_text
is schema:about of	named entity 'human' named entity 'Pipistrellus' named entity 'total' named entity 'spike' named entity 'JANUARY' named entity 'YAK' named entity 'Our' named entity 'structural' named entity 'bats' named entity 'subsequent' named entity 'strains' named entity 'investigate' named entity 'severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'current outbreak' named entity 'coronavirus' named entity 'betacoronavirus' named entity 'outbreak' named entity 'phylogenetic' named entity 'HKU5' named entity 'glycoprotein' named entity 'Pipistrellus abramus' named entity 'YAK' named entity 'intermediate host' named entity 'SARS-CoV-2' named entity 'phylogeny' named entity 'investigate' named entity 'host cell' named entity 'nucleocapsid' named entity 'gammacoronaviruses' named entity 'structural proteins' named entity 'neighbor-joining method' named entity 'betacoronaviruses' named entity 'NCBI' named entity 'SARS-CoV-2' named entity 'web server' named entity 'SARS-CoV-2' named entity 'therapeutic targets' named entity 'N-terminal' named entity 'coronavirus' named entity 'SARS-CoV-2' named entity 'glycoprotein' named entity 'genome' named entity 'COVID' named entity 'glycoproteins' named entity 'normalized score' named entity 'MERS' named entity 'gammacoronaviruses' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'Wuhan' named entity 'conserved domains' named entity 'C-terminal' named entity 'glycoproteins' named entity 'membrane proteins' named entity 'phylogenetic relationships' named entity 'phylogenetic tree' named entity 'betacoronavirus' named entity 'open reading frames' named entity 'genomes' named entity 'ORF1' named entity 'glycoproteins' named entity 'envelope protein' named entity 'homology' named entity 'glycoproteins' named entity 'China' named entity 'genomes' named entity 'gammacoronaviruses' named entity 'N-terminal' named entity 'phylogenetic study' named entity 'camel' named entity 'conserved domains' named entity 'C-terminal domains' named entity 'Bos grunniens' named entity 'Conserved Domain Database' named entity 'glycoprotein' named entity 'ORF2' named entity 'coronavirus' named entity 'pangolin'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software