About: Repurposing calcium channel blockers as antiviral drugs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Repurposing calcium channel blockers as antiviral drugs
Creator	Jayaseelan, Vijayashree Paramasivam, Arumugam
Source	Medline; PMC
abstract	The current pandemic caused by the SARS-CoV-2 has claimed over a half a million lives within a very short span of time. A therapeutic drug which could prevent the entry and propagation of the virus is the need of the hour. Several lines of evidence collected from experimental studies older than three decades have pointed out the fact that inhibiting calcium entry into cells can affect vital steps in the lifecycle of viruses. Hence, calcium channel blockers may be considered as an effective measure in the containment of the viruses. This commentary throws light two scientific papers although with divergent facts converging at a point by suggesting a promising treatment option for CoVID-19 (Fang et al. Lancet Respir Med 8:e21, 2020; Straus et al. J Virol 94:e00426, 2020).
has issue date	2020-08-19(xsd:dateTime)
bibo:doi	10.1007/s12079-020-00579-y
bibo:pmid	32815099
has license	no-cc
sha1sum (hex)	ad93b319ddcd6f7df8fdca8e411a9f2eac8ea21a
schema:url	https://doi.org/10.1007/s12079-020-00579-y
resource representing a document's title	Repurposing calcium channel blockers as antiviral drugs
has PubMed Central identifier	PMC7438026
has PubMed identifier	32815099
schema:publication	J Cell Commun Signal
resource representing a document's body	covid:ad93b319ddcd6f7df8fdca8e411a9f2eac8ea21a#body_text
is schema:about of	named entity 'PREVENT' named entity 'pandemic' named entity 'converging' named entity 'promising' named entity 'antiviral drugs' named entity 'virus' named entity 'viruses' named entity 'Lancet' named entity 'calcium' named entity 'viral infection' named entity 'anti-viral' named entity 'viral protein' named entity 'virus infection' named entity 'SV40' named entity 'over-expression' named entity 'signal transduction pathways' named entity 'influenza A virus' named entity 'viruses' named entity 'measles virus' named entity 'genome-wide' named entity 'calcium channel blockers' named entity 'calcium channels' named entity 'mitochondria' named entity 'Ebola' named entity 'viral infections' named entity 'SARS-CoV' named entity 'ARBs' named entity 'receptor' named entity 'endoplasmic reticulum' named entity 'calcium influx' named entity 'hypertension' named entity 'D522' named entity 'West Nile virus' named entity 'diabetes' named entity 'angiotensin II' named entity 'efflux' named entity 'Subunit' named entity 'infection' named entity 'Golgi apparatus' named entity 'rhinovirus' named entity 'ACE2' named entity 'lung' named entity 'host response' named entity 'calcium signalling' named entity 'Merkel cell polyomavirus' named entity 'host cells' named entity 'capsid' named entity 'cytosolic' named entity 'calcium' named entity 'hypertension' named entity 'genetic variants' named entity 'extracellular' named entity 'host cell' named entity 'voltage gated calcium channel' named entity 'anti-hypertensive drugs' named entity 'ibuprofen' named entity 'infection' named entity 'endosomes' named entity 'Angiotensin converting enzyme 2' named entity 'fusogenic' named entity 'anti-hypertensives' named entity 'epithelial cells' named entity 'TRP' named entity 'SV40' named entity 'VGCC' named entity 'virus' named entity 'TRP' named entity 'infection' named entity 'cytosolic' named entity 'angina' named entity 'ACE inhibitors' named entity 'calcium homeostasis' named entity 'RSV' named entity 'calcium channels' named entity 'nuclear transport' named entity 'glycoprotein' named entity 'virus' named entity 'Viruses' named entity 'prescription drugs' named entity 'hypertension'

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