About: Model of end stage liver disease (MELD) score greater than 23 predicts length of stay in the ICU but not mortality in liver transplant recipients

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About: Model of end stage liver disease (MELD) score greater than 23 predicts length of stay in the ICU but not mortality in liver transplant recipients Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Model of end stage liver disease (MELD) score greater than 23 predicts length of stay in the ICU but not mortality in liver transplant recipients
Creator	Béchir, Markus Clavien, Pierre-Alain Dutkowski, Philipp Oberkofler, Christian Schuepbach, Reto Stocker, Reto Stover, John
topic	covid:ac7842dd7a78a32daf150fb200ef6dafc84d9d8b#this
source	PMC
abstract	INTRODUCTION: The impact of model of end stage liver disease (MELD) score on postoperative morbidity and mortality is still elusive, especially for high MELD. There are reports of poorer patient outcome in transplant candidates with high MELD score, others though report no influence of MELD score on outcome and survival. METHODS: We retrospectively analyzed data of 144 consecutive liver transplant recipients over a 72-month period in our transplant unit, from January 2003 until December 2008 and performed uni- and multivariate analysis for morbidity and mortality, in particular to define the influence of MELD to these parameters. RESULTS: This study identified MELD score greater than 23 as an independent risk factor of morbidity represented by intensive care unit (ICU) stay longer than 10 days (odds ratio 7.0) but in contrast had no negative impact on mortality. Furthermore, we identified transfusion of more than 7 units of red blood cells as independent risk factor for mortality (hazard ratio 7.6) and for prolonged ICU stay (odds ratio [OR] 7.8) together with transfusion of more than 10 units of fresh frozen plasma (OR 11.6). Postoperative renal failure is a strong predictor of morbidity (OR 7.9) and postoperative renal replacement therapy was highly associated with increased mortality (hazard ratio 6.8), as was hepato renal syndrome prior to transplantation (hazard ratio 13.2). CONCLUSIONS: This study identified MELD score greater than 23 as an independent risk factor of morbidity represented by ICU stay longer than 10 days but in contrast had no negative impact on mortality. This finding supports the transplantation of patients with high MELD score but only with knowledge of increased morbidity.
has issue date	2010-06-15(xsd:dateTime)
bibo:doi	10.1186/cc9068
bibo:pmid	20550662
has license	cc-by
sha1sum (hex)	ac7842dd7a78a32daf150fb200ef6dafc84d9d8b
schema:url	https://doi.org/10.1186/cc9068
resource representing a document's title	Model of end stage liver disease (MELD) score greater than 23 predicts length of stay in the ICU but not mortality in liver transplant recipients
has PubMed Central identifier	PMC2911764
has PubMed identifier	20550662
schema:publication	Crit Care
resource representing a document's body	covid:ac7842dd7a78a32daf150fb200ef6dafc84d9d8b#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/ac7842dd7a78a32daf150fb200ef6dafc84d9d8b
is schema:about of	named entity 'INCREASED MORTALITY' named entity 'ICU STAY' named entity 'UNITS' named entity 'PERFORMED' named entity 'OUR' named entity 'MORBIDITY AND MORTALITY' named entity '11.6' named entity 'RESULTS' named entity 'PRIOR TO' named entity 'UNI' named entity 'REPORTS' named entity 'INDEPENDENT RISK FACTOR' named entity 'INFLUENCE' named entity 'SCORE' named entity 'MELD SCORE' named entity 'PATIENTS' named entity 'POSTOPERATIVE RENAL FAILURE' named entity 'ASSOCIATED WITH' named entity 'IMPACT' named entity 'MELD' named entity 'morbidity' named entity 'sepsis' named entity 'MELD' named entity 'MELD' named entity 'ICU' named entity 'hazard ratio' named entity 'MELD' named entity 'MELD' named entity 'morbidity' named entity 'morbidity' named entity 'end stage' named entity 'odds ratio' named entity 'morbidity' named entity 'liver transplant' named entity 'MELD' named entity 'liver transplant' named entity 'morbidity' named entity 'hazard ratio' named entity 'Critical Care' named entity 'RESEARCH Model' named entity 'liver transplant' named entity 'renal failure' named entity 'ESLD' named entity 'liver transplantation' named entity 'ICU' named entity 'ICU' named entity 'MELD' named entity 'RRT' named entity 'ICU' named entity 'probiotics' named entity 'ICU' named entity 'red blood cells' named entity 'RRT' named entity 'ICU' named entity 'MELD' named entity 'biopsy' named entity 'risk factors' named entity 'RRT' named entity 'end-stage liver disease' named entity 'aspartate aminotransferase' named entity 'multivariate analysis' named entity 'FFP' named entity 'Allogeneic' named entity 'renal failure' named entity 'liver transplant' named entity 'RBC' named entity 'risk factors' named entity 'fibrinogen' named entity 'MELD' named entity 'peak levels' named entity 'RRT' named entity 'ICU' named entity 'morbidity'

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