About: Immunotherapy of Bacillus Calmette-Guérin by targeting macrophages against bladder cancer in a NOD/scid (IL2Rg-/−) mouse model

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About: Immunotherapy of Bacillus Calmette-Guérin by targeting macrophages against bladder cancer in a NOD/scid (IL2Rg-/−) mouse model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunotherapy of Bacillus Calmette-Guérin by targeting macrophages against bladder cancer in a NOD/scid (IL2Rg-/−) mouse model
Creator	Zhang, Xian Cheng, Lin Luo, Min Zeng, Xing Liu, Chun-Ping Tan, Qing-Long Xu, Wen-Xing Zhou, Chang-Yuan
Source	Medline; PMC
abstract	Bacillus Calmette-Guérin (BCG) is considered to be a successful biotherapy for treating bladder cancer (BCa). However, the underlying mechanisms of BCG have not been completely clarified, to date. The role of macrophages in BCG therapy for BCa has still not been determined in vivo. In the present study, the role and potential mechanism of BCG (0.25, 1.25 and 6.25 µg/mouse; intravenous) immunotherapy for BCa was investigated in a NOD/scid (IL2Rg−/−) (NSI) mouse model by targeting macrophages in vivo. Notably, it was observed that NSI mice with T24 BCa cells displayed high levels of the macrophage marker CD11b(+) F4/80(+) after injection via the tail vein of live BCG, as well as a significant reduction in tumor volume. The levels of the inflammatory and macrophage maturation cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6, IL-12P70, TNF superfamily member 11 and monocyte chemotactic protein 1, were significantly increased in the serum and the tumor supernatant compared to that in normal control subjects. Furthermore, BCG promoted the expression of the pro-differential genes Spi-1 proto-oncogene, early growth response protein 1, nuclear factor (NF)-κB and proto-oncogene c-Fos in bone marrow. In conclusion, these observations indicate that the injection of live BCG can target macrophages against bladder tumor growth in vivo. The mechanism is likely related to the promotion of macrophage maturation, immune activation and increased numbers of macrophages infiltrating the bladder tumor.
has issue date	2020-04-22(xsd:dateTime)
bibo:doi	10.3892/mmr.2020.11090
bibo:pmid	32319653
has license	cc-by-nc-nd
sha1sum (hex)	ab4adffefee21216d50f14fce0a696466077f6d8
schema:url	https://doi.org/10.3892/mmr.2020.11090
resource representing a document's title	Immunotherapy of Bacillus Calmette-Guérin by targeting macrophages against bladder cancer in a NOD/scid (IL2Rg-/−) mouse model
has PubMed Central identifier	PMC7248479
has PubMed identifier	32319653
schema:publication	Mol Med Rep
resource representing a document's body	covid:ab4adffefee21216d50f14fce0a696466077f6d8#body_text
is schema:about of	named entity 'PROMOTION' named entity 'CD11B' named entity 'BAB' named entity 'NORMAL CONTROL' named entity 'TREATING' named entity 'MONOCYTE CHEMOTACTIC PROTEIN 1' named entity 'IL2RG' named entity 'NSI' named entity 'BcG' named entity 'early growth response protein 1' named entity 'c-Fos' named entity 'BcG' named entity 'BcG' named entity 'BcG' named entity 'il2rg' named entity 'high levels' named entity 'scid' named entity 'tumor necrosis factor' named entity 'phenotype' named entity 'carcinoma' named entity 'rna' named entity 'F4/80' named entity 'il-8' named entity 'bone marrow' named entity 'Photomicrographs' named entity 'spleen' named entity 'vascularization' named entity 'serum' named entity 'mRNA expression' named entity 'penicillin' named entity 'chemokines' named entity 'ranKl' named entity 'M-cSF' named entity 'cytokines' named entity 'dr. William B. coley' named entity 'Guangzhou' named entity 'humidity' named entity 'chemotaxis' named entity 'one-way ANOVA' named entity 'mice' named entity 'BcG' named entity 'tail vein' named entity 'mouse model' named entity 'monocytes' named entity 'BcG' named entity 'monocyte' named entity 'Sloan-Kettering' named entity 'bone marrow' named entity 'control group' named entity 'McP-1' named entity 'ligand' named entity 'il-6' named entity 'american Type culture collection' named entity 'cybernetics' named entity 'treatment group' named entity 'secretion' named entity 'humoral immune response' named entity 'cdna' named entity 'macrophages' named entity 'BCG' named entity 'Pu.1' named entity 'mouse model' named entity 'mice' named entity 'BcG' named entity 'cDNA' named entity 'quantitative PCR' named entity 'citrate' named entity 'internal control' named entity 'tumor' named entity 'electronic balance' named entity 'bladder cancer' named entity 'antibody' named entity 'muscle' named entity 'CD11b'

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