About: Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine

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About: Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine
Creator	Sun, Jun Wu, Shaoping Kocher, Jacob Li, Guohua Liu, Fangning Wen, Ke Yang, Xingdong Yuan, Lijuan Zhang, Yongguo
Source	Medline; PMC
abstract	BACKGROUND: Human rotavirus (HRV) is the most important cause of severe diarrhea in infants and young children. Probiotic Lactobacillus rhamnosus GG (LGG) reduces rotavirus infection and diarrhea. However, the molecular mechanisms of LGG-mediated protection from rotavirus infection are poorly understood. Autophagy plays an essential role in responses to microbial pathogens. However, the role of autophagy in HRV infection and LGG treatment is unknown. We hypothesize that rotavirus gastroenteritis activates autophagy and that LGG suppresses virus-induced autophagy and prevents intestinal damage in infected piglets. METHODS: We used LGG feeding to combat viral gastroenteritis in the gnotobiotic pig model of virulent HRV infection. RESULTS: We found that LGG feeding did not increase autophagy, whereas virus infection induced autophagy in the piglet intestine. Virus infection increased the protein levels of the autophagy markers ATG16L1 and Beclin-1 and the autophagy regulator mTOR. LGG treatment during viral gastroenteritis reduced autophagy marker expression to normal levels, induced apoptosis and partially prevented virus-induced tissue damage. CONCLUSION: Our study provides new insights into virus-induced autophagy and LGG suppression of uncontrolled autophagy and intestinal injury. A better understanding of the antiviral activity of LGG will lead to novel therapeutic strategies for infant infectious diseases.
has issue date	2013-08-07(xsd:dateTime)
bibo:doi	10.1186/1757-4749-5-22
bibo:pmid	23924832
has license	cc-by
sha1sum (hex)	aab412e1a2fee75cf3e3fbc911d985ac004f866e
schema:url	https://doi.org/10.1186/1757-4749-5-22
resource representing a document's title	Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine
has PubMed Central identifier	PMC3750464
has PubMed identifier	23924832
schema:publication	Gut Pathog
resource representing a document's body	covid:aab412e1a2fee75cf3e3fbc911d985ac004f866e#body_text
is schema:about of	named entity 'HUMAN ROTAVIRUS' named entity 'MONO' named entity 'PROBIOTIC' named entity 'damage' named entity 'piglets' named entity 'Human' named entity 'infected' named entity 'reduces' named entity 'rotavirus' named entity 'INDUCED' named entity 'UNDERSTOOD' named entity 'DAMAGE' named entity 'PROBIOTIC' named entity 'ASSOCIATION' named entity 'PIGLET' named entity 'YOUNG CHILDREN' covid:arg/aab412e1a2fee75cf3e3fbc911d985ac004f866e named entity 'PLAYS' named entity 'INTESTINAL' named entity 'MECHANISMS' named entity 'DIARRHEA' named entity 'VIRUS' named entity 'ROLE' named entity 'INDUCED' named entity 'AUTOPHAGY' named entity 'TREATMENT' named entity 'POORLY' named entity 'MEDIATED' named entity 'LGG' named entity 'LACTOBACILLUS RHAMNOSUS GG' named entity 'UNKNOWN' named entity 'MICROBIAL PATHOGENS' named entity 'AUTOPHAGY' named entity 'PROTECTION' named entity 'ACTIVATES' named entity 'SEVERE DIARRHEA' named entity 'LACTOBACILLUS RHAMNOSUS GG' named entity 'SUPPRESSES' named entity 'INFECTION' named entity 'ROTAVIRUS GASTROENTERITIS' named entity 'HUMAN ROTAVIRUS' named entity 'ROTAVIRUS INFECTION' named entity 'INFANTS' named entity 'RESPONSES' named entity 'SUPPRESSES' named entity 'IMPORTANT' named entity 'ESSENTIAL' named entity 'CAUSE' named entity 'BACKGROUND' named entity 'INTESTINE' named entity 'HRV' named entity 'MOLECULAR' named entity 'INFECTED' named entity 'PREVENTS' named entity 'gastroenteritis' named entity 'However' named entity 'severe' named entity 'Lactobacillus rhamnosus' named entity 'rotavirus' named entity 'rotavirus' named entity 'microbial' named entity 'rotavirus gastroenteritis' named entity 'Autophagy' named entity 'LGG' named entity 'infection' named entity 'autophagy' named entity 'autophagy' named entity 'LGG' named entity 'rotavirus' named entity 'rotavirus' named entity 'autophagy' named entity 'gnotobiotic' named entity 'Claudin-2'

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