About: In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect

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About: In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
Creator	Raoult, Didier Colson, Philippe Rolain, Jean-Marc Scola, Bernard Andreani, Julien Boxberger, Manon Colson, J-M Duflot, Isabelle Jardot, Priscilla Le Bideau, Marion Le Bideau, Andreani Rolain, Wurtz Rolland, Clara Scola B, La Wurtz, Nathalie
Source	Elsevier; Medline; PMC
abstract	Abstract Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung.
has issue date	2020-04-25(xsd:dateTime)
bibo:doi	10.1016/j.micpath.2020.104228
bibo:pmid	32344177
has license	els-covid
sha1sum (hex)	aa942370307672dd0c2013494e35b610a8d68411
schema:url	https://doi.org/10.1016/j.micpath.2020.104228
resource representing a document's title	In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
has PubMed Central identifier	PMC7182748
has PubMed identifier	32344177
schema:publication	Microb Pathog
resource representing a document's body	covid:aa942370307672dd0c2013494e35b610a8d68411#body_text
is schema:about of	named entity 'In vitro' named entity 'Microbial' named entity 'testing' named entity 'HYDROXYCHLOROQUINE' named entity 'PATHOGENESIS' named entity 'COMBINED' named entity 'SARS-COV-2' named entity 'MICROBIAL' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'hydroxychloroquine' named entity 'lyses' named entity 'viruses' named entity 'clinical study' named entity 'Human coronaviruses' named entity 'hydroxychloroquine' named entity 'H60' named entity 'azithromycin' named entity 'cytotoxicity' named entity 'Kruskal-Wallis test' named entity 'multiple comparison' named entity 'potency' named entity 'positive controls' named entity 'antiviral effect' named entity 'hydroxychloroquine' named entity 'positive control' named entity 'Teicoplanin' named entity 'Coronavirus' named entity 'azithromycin' named entity 'RNA' named entity 'intracellular' named entity 'Chloroquine' named entity 'epidemic' named entity 'azithromycin' named entity 'hydroxychloroquine' named entity 'hydroxychloroquine' named entity 'quinine' named entity 'P-values' named entity 'SARS-CoV-2' named entity 'hydroxychloroquine' named entity 'P-value' named entity 'SARS-CoV' named entity 'viral load' named entity 'SARS-CoV' named entity 'drug repurposing' named entity 'hydroxychloroquine' named entity 'azithromycin' named entity 'mice models' named entity 'antibacterial' named entity 'SARS-CoV-2' named entity 'hydroxychloroquine' named entity 'antiviral activity' named entity '1, 2' named entity 'Azithromycin' named entity 'Coronavirus' named entity 'Zika' named entity 'synergistic effect' named entity 'azithromycin' named entity 'Microbial Pathogenesis' named entity 'doi' named entity 'viral replication' named entity 'SARS-CoV-2' named entity 'Vero E6' named entity 'vaccine' named entity 'azithromycin' named entity 'hydroxychloroquine' named entity 'macrolide'

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