About: THE INTRACELLULAR CARGO RECEPTOR ERGIC-53 IS REQUIRED FOR THE PRODUCTION OF INFECTIOUS ARENAVIRUS, CORONAVIRUS, AND FILOVIRUS PARTICLES

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About: THE INTRACELLULAR CARGO RECEPTOR ERGIC-53 IS REQUIRED FOR THE PRODUCTION OF INFECTIOUS ARENAVIRUS, CORONAVIRUS, AND FILOVIRUS PARTICLES Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	THE INTRACELLULAR CARGO RECEPTOR ERGIC-53 IS REQUIRED FOR THE PRODUCTION OF INFECTIOUS ARENAVIRUS, CORONAVIRUS, AND FILOVIRUS PARTICLES
Creator	Botten, Jason Eisenhauer, Philip Zhang, Bin Russo, Joanne Cornillez-Ty, Cromwell Do, Danh King, Benjamin Liao, Lujian Taatjes, Douglas Thali, Markus Zheng, Chunlei Ballif, Bryan Boyson, Jonathan Klaus, Joseph Mason, Anne Yates Iii, John
Source	Elsevier; Medline; PMC
abstract	Arenaviruses and hantaviruses cause severe and often fatal diseases in humans. Little is known regarding host proteins required for their propagation. We identified human proteins that interact with the glycoproteins (GPs) of a prototypic arenavirus and hantavirus and show that the lectin ERGIC-53 - a cargo receptor required for cellular glycoprotein trafficking within the early exocytic pathway - associates with arenavirus, hantavirus, coronavirus, orthomyxovirus, and filovirus GPs. ERGIC-53 binds to arenavirus GPs through a lectin-independent mechanism, traffics to arenavirus budding sites, and is incorporated into arenavirus particles. ERGIC-53 is required for arenavirus, coronavirus, and filovirus propagation; in its absence, GP-containing virus particles form, but are noninfectious due, in part, to their inability to attach to host cells. Thus, we have identified a class of pathogen-derived ERGIC-53 ligands, a lectin-independent basis for their association with ERGIC-53, and a role for ERGIC-53 in the propagation of several highly pathogenic RNA virus families.
has issue date	2013-11-01(xsd:dateTime)
bibo:doi	10.1016/j.chom.2013.10.010
bibo:pmid	24237698
has license	hybrid-oa
sha1sum (hex)	a98cb78560aeea0f7e3e21df8359a9430ffce55d
schema:url	https://doi.org/10.1016/j.chom.2013.10.010
resource representing a document's title	THE INTRACELLULAR CARGO RECEPTOR ERGIC-53 IS REQUIRED FOR THE PRODUCTION OF INFECTIOUS ARENAVIRUS, CORONAVIRUS, AND FILOVIRUS PARTICLES
has PubMed Central identifier	PMC3999090
has PubMed identifier	24237698
schema:publication	Cell Host & Microbe
resource representing a document's body	covid:a98cb78560aeea0f7e3e21df8359a9430ffce55d#body_text
is schema:about of	named entity 'protein' named entity 'hantavirus' named entity 'lectin' named entity 'Receptor' named entity 'lysates' named entity 'plasmid' named entity 'vaccines' named entity 'lysates' named entity 'ERGIC-53' named entity 'ERGIC-53' named entity 'ERGIC-53' named entity 'mannose' named entity 'protein' named entity 'SARS CoV' named entity 'plasma membrane' named entity 'ERGIC-53' named entity 'ERGIC-53' named entity 'Western Blot' named entity 'proteomics' named entity 'Appenzeller' named entity 'ERGIC-53' named entity 'ERGIC-53' named entity 'ERGIC-53' named entity 'infection' named entity 'plasma membrane' named entity 'antibody' named entity 'COPI' named entity 'arenavirus' named entity 'infection' named entity 'virion' named entity 'viral particles' named entity 'protein' named entity 'viral genome' named entity 'digestion' named entity 'ERGIC' named entity 'C-terminal' named entity 'LMAN1' named entity 'GP2' named entity '0.01' named entity 'GPs' named entity 'glycoproteins' named entity 'SARS CoV' named entity 'ERGIC-53' named entity 'siRNA' named entity 'arenavirus' named entity 'ERGIC-53' named entity 'region 2' named entity 'C-terminal region' named entity 'viral particles' named entity 'vesicular' named entity 'null cell' named entity 'Hantaviruses' named entity 'actin' named entity 'maturation steps' named entity 'renin receptor' named entity 'ERGIC-53' named entity 'biotin' named entity 'C-terminal' named entity 'viral RNAs' named entity 'protein' named entity 'arenavirus' named entity 'Appenzeller' named entity 'A12' named entity 'biotin' named entity 'cis-Golgi' named entity 'arenavirus'

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