About: Hypofibrinolytic state and high thrombin generation may play a major role in sars‐cov2 associated thrombosis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Hypofibrinolytic state and high thrombin generation may play a major role in sars‐cov2 associated thrombosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hypofibrinolytic state and high thrombin generation may play a major role in sars‐cov2 associated thrombosis
Creator	Argaud, Laurent Marcotte, Guillaume Simon, Marie Benoit, Remi Bonnet, Aurelie Cardiologique, Hôpital Dargaud, Yesim David, Jean Desmurs-Clavel, Helene Negrier, Claude Nougier, Christophe Pradel, Louis
Source	Medline; PMC
abstract	BACKGROUND: Thirty percent of Covid‐19 patients admitted to intensive care units present with thrombotic complications despite thromboprophylaxis. Bed resting, obesity, hypoxia, coagulopathy, acute excessive inflammation are potential mechanisms reported by previous studies. Better understanding of the underlying mechanisms leading to thrombosis is crucial for developing more appropriate prophylaxis and treatment strategies. OBJECTIVE: We aimed to assess fibrinolytic activity and thrombin generation in 78 Covid‐19 patients. PATIENTS AND METHODS: Forty eight patients admitted to intensive care unit (ICU) and 30 patients admitted to the internal medicine department were included in the study. All patients received thromboprophylaxis. We measured fibrinolytic parameters (tPA, PAI‐1, TAFI, alpha2 anti‐plasmin, and tPA‐modified ROTEM), thrombin generation, and other coagulation tests (D‐dimer, fibrinogen, FVIII, antithrombin). RESULTS AND CONCLUSIONS: We observed two key findings: a high thrombin generation capacity which remained within normal values despite heparin therapy and a hypofibrinolysis mainly associated with increased PAI‐1 levels. A modified ROTEM (TEM‐tPA) is able to detect both hypercoagulability and hypofibrinolysis simultaneously in Covid‐19 patients with thrombosis.
has issue date	2020-07-15(xsd:dateTime)
bibo:doi	10.1111/jth.15016
bibo:pmid	32668058
has license	no-cc
sha1sum (hex)	a98887417ea4176318da3c158145fa3e57c47078
schema:url	https://doi.org/10.1111/jth.15016
resource representing a document's title	Hypofibrinolytic state and high thrombin generation may play a major role in sars‐cov2 associated thrombosis
has PubMed Central identifier	PMC7405476
has PubMed identifier	32668058
schema:publication	J Thromb Haemost
resource representing a document's body	covid:a98887417ea4176318da3c158145fa3e57c47078#body_text
is schema:about of	named entity 'THROMBOSIS' named entity 'Covid-19' named entity 'PAI-1' named entity 'Haemonetics' named entity 'TAFI' named entity 'fibrinolysis' named entity 'ICU' named entity 'ICU' named entity 'fibrinogen' named entity 'tPA' named entity 'infection' named entity 'exogenous' named entity 'lung' named entity 'ICU' named entity 'fibrin' named entity 'San Diego' named entity 'TAFI' named entity 'thrombotic complications' named entity 'Covid' named entity 'thrombogenic' named entity 'hypercoagulable state' named entity 'TAFI' named entity 'hypercoagulability' named entity 'fibrinolytic' named entity 'fibrinolysis' named entity 'ICU' named entity 'TAFI' named entity 'ICU' named entity 'thrombin' named entity 'COVID-19' named entity 'heparin' named entity 'Spearman correlation' named entity 'hypercoagulability' named entity 'ICU' named entity 'empirical treatment' named entity 'PAI-1' named entity 'standard deviations' named entity 'thrombin' named entity 'Antithrombin' named entity 'Covid' named entity 'antigen' named entity 'Covid' named entity 'thrombosis' named entity 'PAI-1' named entity 'deep vein thromboses' named entity 'pulmonary embolisms' named entity 'Asnières-sur-Seine' named entity 'Fibrinolysis' named entity 'venous thrombosis' named entity 'thrombosis' named entity 'coagulation' named entity 'Covid-19' named entity 'tPA' named entity 'animal models' named entity 'anti-coagulant' named entity 'arrhythmia' named entity 'Covid' named entity 'respiratory failure' named entity 'thrombotic complications' named entity 'plasma levels' named entity 'epidemic' named entity 'fibrin' named entity 'trauma patients' named entity 'hypercoagulable' named entity 'Paris' named entity 'observational study' named entity 'heparin' named entity 'coagulation' named entity 'clinical trial' named entity 'bleeding disorder'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software