About: Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections

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About: Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections
Creator	Margaroli, Camilla Stephenson, Susan Tirouvanziam, Rabindra Brown, Milton Dobosh, Brian Fitzpatrick, Anne Giacalone, Vincent Grunwell, Jocelyn
Source	Medline; PMC
abstract	Neutrophils are recruited to the airways of patients with acute respiratory distress syndrome (ARDS) where they acquire an activated pro-survival phenotype with an enhanced respiratory burst thought to contribute to ARDS pathophysiology. Our in vitro model enables blood neutrophil transepithelial migration into cell-free tracheal aspirate fluid from patients to recapitulate the primary airway neutrophil phenotype observed in vivo. Neutrophils transmigrated through our model toward airway fluid from children with lower respiratory viral infections coinfected with bacteria had elevated levels of neutrophil activation markers but paradoxically exhibited an inability to kill bacteria and a defective respiratory burst compared with children without bacterial coinfection. The airway fluid from children with bacterial coinfections had higher levels of neutrophil elastase activity, as well as myeloperoxidase levels compared to children without bacterial coinfection. Neutrophils transmigrated into the aspirate fluid from children with bacterial coinfection showed decreased respiratory burst and killing activity against H. influenzae and S. aureus compared to those transmigrated into the aspirate fluid from children without bacterial coinfection. Use of a novel transmigration model recapitulates this pathological phenotype in vitro that would otherwise be impossible in a patient, opening avenues for future mechanistic and therapeutic research.
has issue date	2019-02-27(xsd:dateTime)
bibo:doi	10.1038/s41598-019-39726-w
bibo:pmid	30814584
has license	cc-by
sha1sum (hex)	a92d2df5aae260091456d3a65800c01cca79d599
schema:url	https://doi.org/10.1038/s41598-019-39726-w
resource representing a document's title	Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections
has PubMed Central identifier	PMC6393569
has PubMed identifier	30814584
schema:publication	Sci Rep
resource representing a document's body	covid:a92d2df5aae260091456d3a65800c01cca79d599#body_text
is schema:about of	named entity 'transmigrated' named entity 'compared' named entity 'coinfections' named entity 'Viral' named entity 'RESPIRATORY' named entity 'VIRAL INFECTIONS' named entity 'ARDS' named entity 'NEUTROPHIL PHENOTYPE' named entity 'OBSERVED' named entity 'TRANSMIGRATION' named entity 'S. AUREUS' named entity 'KILLING' named entity 'CONTRIBUTE ' named entity 'ELEVATED' named entity 'MODEL' named entity 'THOUGHT' named entity 'ASPIRATE' named entity 'BLOOD NEUTROPHIL' named entity 'USE OF' named entity 'PATIENTS' named entity 'INABILITY' named entity 'ACQUIRE' named entity 'COMPARED' named entity 'AIRWAY FLUID' named entity 'NEUTROPHIL ACTIVATION' named entity 'MYELOPEROXIDASE' named entity 'PATIENT' named entity 'NEUTROPHIL ELASTASE' named entity 'DEFECTIVE' named entity 'WHERE' named entity 'COINFECTION' named entity 'LOWER' named entity 'PATHOPHYSIOLOGY' named entity 'CELL' named entity 'PHENOTYPE' named entity 'MARKERS' named entity 'H. INFLUENZAE' named entity 'LEVELS' named entity 'ENABLES' named entity 'FREE' covid:arg/a92d2df5aae260091456d3a65800c01cca79d599 named entity 'IMPOSSIBLE' named entity 'FUTURE' named entity 'VIRAL AND' named entity 'IN VITRO' named entity 'AIRWAYS' named entity 'DUE TO' named entity 'CHILDREN' named entity 'BACTERIAL' named entity 'ACUTE RESPIRATORY FAILURE' named entity 'ELASTASE ACTIVITY' named entity 'IN VIVO' named entity 'OPENING' named entity 'BACTERIAL' named entity 'TRACHEAL ASPIRATE' named entity 'PATHOLOGICAL' named entity 'PRO-SURVIVAL' named entity 'IN VITRO MODEL' named entity 'MIGRATION' named entity 'CHILDREN' named entity 'ACTIVATED' named entity 'AIRWAY' named entity 'LOWER RESPIRATORY TRACT' named entity 'NEUTROPHIL DYSFUNCTION' named entity 'DECREASED' named entity 'OUR' named entity 'HIGHER' named entity 'NOVEL' named entity 'KILL' named entity 'RESPIRATORY BURST' named entity 'ACTIVITY' named entity 'NEUTROPHILS' named entity 'PRIMARY' named entity 'FLUID'

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