About: Virus–drug interactions—molecular insight into immunosuppression and HCV

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Virus–drug interactions—molecular insight into immunosuppression and HCV
Creator	Pan, Q
Source	Medline; PMC
abstract	Liver transplantation is an effective treatment for end-stage liver disease that is attributable to chronic HCV infection. However, long-term outcomes are compromised by universal virological recurrence in the graft. Reinfection that occurs after transplantation has increased resistance to current interferon-based antiviral therapy and often leads to accelerated development of cirrhosis. Important risk factors for severe HCV recurrence are linked to immunosuppression. Owing to the lack of good randomized, controlled trials, the optimal choice of immunosuppressants is still debated. By contrast, much progress has been made in the understanding of HCV biology and the antiviral action of interferons. These new insights have greatly expanded our knowledge of the molecular interplay between HCV and immunosuppressive drugs. In this article, we explore the effect of different immunosuppressants on the complex cellular events involved in HCV infection and interferon signalling. Potential implications for clinical practice and future drug development are discussed.
has issue date	2012-04-17(xsd:dateTime)
bibo:doi	10.1038/nrgastro.2012.67
bibo:pmid	22508161
has license	no-cc
sha1sum (hex)	a8de890a758fac40b951d6d0c12c3a0a8a6d3712
schema:url	https://doi.org/10.1038/nrgastro.2012.67
resource representing a document's title	Virus–drug interactions—molecular insight into immunosuppression and HCV
has PubMed Central identifier	PMC7097508
has PubMed identifier	22508161
schema:publication	Nat Rev Gastroenterol Hepatol
resource representing a document's body	covid:a8de890a758fac40b951d6d0c12c3a0a8a6d3712#body_text
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