About: On the possible role of robustness in the evolution of infectious diseases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	On the possible role of robustness in the evolution of infectious diseases
Creator	Turner, Paul Ogbunugafor, C Pease, James
Source	PMC
abstract	Robustness describes the capacity for a biological system to remain canalized despite perturbation. Genetic robustness affords maintenance of phenotype despite mutational input, necessarily involving the role of epistasis. Environmental robustness is phenotypic constancy in the face of environmental variation, where epistasis may be uninvolved. Here we discuss genetic and environmental robustness, from the standpoint of infectious disease evolution, and suggest that robustness may be a unifying principle for understanding how different disease agents evolve. We focus especially on viruses with RNA genomes due to their importance in the evolution of emerging diseases and as model systems to test robustness theory. We present new data on adaptive constraints for a model RNA virus challenged to evolve in response to UV radiation. We also draw attention to other infectious disease systems where robustness theory may prove useful for bridging evolutionary biology and biomedicine, especially the evolution of antibiotic resistance in bacteria, immune evasion by influenza, and malaria parasite infections.
has issue date	2010-06-30(xsd:dateTime)
bibo:doi	10.1063/1.3455189
bibo:pmid	20590337
has license	cc-by
sha1sum (hex)	a864ea529dd03034ad7bf347e1dee420a36ae8d2
schema:url	https://doi.org/10.1063/1.3455189
resource representing a document's title	On the possible role of robustness in the evolution of infectious diseases
has PubMed Central identifier	PMC2909313
has PubMed identifier	20590337
schema:publication	Chaos
resource representing a document's body	covid:a864ea529dd03034ad7bf347e1dee420a36ae8d2#body_text
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