About: Viral antibody titers, immunogenetic markers, and their interrelations in multiple sclerosis patients and controls

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About: Viral antibody titers, immunogenetic markers, and their interrelations in multiple sclerosis patients and controls Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral antibody titers, immunogenetic markers, and their interrelations in multiple sclerosis patients and controls
Creator	Alp6rovitch, A Berr, C Cambon-Thomsen, A Clanet, M Dugoujon, J.-M Puel, J Ruidavets, J.-B
Source	Elsevier; Medline; PMC
abstract	Abstract Our purpose was to investigate possible interrelations between antibody titers against seven viruses (measles, rubella, herpes simplex, mumps, varicella-zoster, coronavirus, cytomegalovirus), HLA-class II antigens, and immunoglobulin Gm allotypes in multiple sclerosis (MS). We studied 57 MS patients and 59 controls with similar age and sex distributions. In MS patients, we found the classical increased frequency of HLA-DR2, HLA-DQw1 and also an excess of Gm (3; ±23; 5*). Mumps antibody levels were higher in MS patients than in controls; elevation was not significant for measles antibodies. Analysis suggests that an association between HLA-DQwl and antibody titers against various viruses exists in controls but is absent in MS patients. In particular, we found that mumps antibody titers were higher in DQwl-positive than in DQwl-negative controls, while there was no significant difference among MS cases. Accordingly, we found that the overall difference between patients and controls was due to the fact that DQwl-positive patients had higher titers than controls, while DQwl-negative cases had similar titers as controls. These findings suggest that biological and molecular characteristics of DQwl might differ in MS patients.
has issue date	1991-06-30(xsd:dateTime)
bibo:doi	10.1016/0198-8859(91)90011-w
bibo:pmid	2066275
has license	els-covid
sha1sum (hex)	a845c20d2ca640c7c19e88adfb96205f7d9ba361
schema:url	https://doi.org/10.1016/0198-8859%2891%2990011-w
resource representing a document's title	Viral antibody titers, immunogenetic markers, and their interrelations in multiple sclerosis patients and controls
has PubMed Central identifier	PMC7134667
has PubMed identifier	2066275
schema:publication	Human Immunology
resource representing a document's body	covid:a845c20d2ca640c7c19e88adfb96205f7d9ba361#body_text
is schema:about of	named entity 'sex' named entity 'Controls' named entity 'Tilers' named entity 'MARKERS' named entity 'VIRAL ANTIBODY' named entity 'ABBREVIATIONS' named entity 'ANTIBODIES' named entity 'DISTRIBUTIONS' covid:arg/a845c20d2ca640c7c19e88adfb96205f7d9ba361 named entity 'MULTIPLE SCLEROSIS' named entity 'ANTIBODY' named entity 'CLASS II' named entity 'HERPES SIMPLEX' named entity 'TO INVESTIGATE' named entity 'POSSIBLE' named entity 'HLA-DR2' named entity 'SIMILAR' named entity 'FOUND' named entity 'VARICELLA' named entity 'IMMUNOGENETIC' named entity 'INCREASED FREQUENCY' named entity 'MUMPS' named entity 'ASSOCIATION' named entity 'ZOSTER' named entity 'THEIR' named entity 'SEVEN' named entity 'EXCESS' named entity 'ELEVATION' named entity 'AGE' named entity 'IMMUNOGLOBIN' named entity 'PURPOSE' named entity 'HLA' named entity 'MULTIPLE SCLEROSIS' named entity 'LEVELS' named entity 'RUBELLA' named entity 'CYTOMEGALOVIRUS' named entity '283' named entity 'HIGHER' named entity 'NOT SIGNIFICANT' named entity 'CORONAVIRUS' named entity 'IMMUNOGLOBULIN GM ALLOTYPES' named entity 'HEAVY CHAIN' named entity 'MEASLES' named entity '28A' named entity 'SEX' named entity 'ANTIGENS' named entity 'OUR' named entity 'MUMPS ANTIBODY' named entity 'CLASSICAL' named entity 'VIRUSES' named entity 'ANALYSIS' named entity 'PATIENTS' named entity 'PATIENTS' named entity 'CONTROLS' named entity 'distributions' named entity 'antibody' named entity 'mumps' named entity 'rubella' named entity 'measles' named entity 'INSERM' named entity 'Villejuif' named entity 'Multiple Sclerosis' named entity 'immunoglobin' named entity 'measles' named entity 'heavy chain' named entity 'measles' named entity 'Mumps' named entity 'coronavirus' named entity 'rubella' named entity 'varicella-zoster' named entity 'HLA' named entity 'HLA' named entity 'INSERM' named entity 'locus' named entity 'alleles'

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