About: West Nile virus genome amplification requires the functional activities of the proteasome

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About: West Nile virus genome amplification requires the functional activities of the proteasome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	West Nile virus genome amplification requires the functional activities of the proteasome
Creator	Mason, Peter Fayzulin, Rafik Gilfoy, Felicia
Source	Elsevier; Medline; PMC
abstract	Abstract The lifecycle of intracellular pathogens, especially viruses, is intimately tied to the macromolecular synthetic processes of their host cell. In the case of positive-stranded RNA viruses, the ability to translate and, thus, replicate their infecting genome is dependent upon hijacking host proteins. To identify proteins that participate in West Nile virus (WNV) replication, we tested the ability of siRNAs designed to knock-down the expression of a large subset of human genes to interfere with replication of WNV replicons. Here we report that multiple siRNAs for proteasome subunits interfered with WNV genome amplification. Specificity of the interference was shown by demonstrating that silencing proteasome subunits did not interfere with Venezuelan equine encephalitis virus replicons. Drugs that blocked proteasome activity were potent inhibitors of WNV genome amplification even if cells were treated 12 h after infection, indicating that the proteasome is required at a post-entry stage(s) of the WNV infection cycle.
has issue date	2009-03-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2008.11.034
bibo:pmid	19101004
has license	els-covid
sha1sum (hex)	a80751d5415f2d5a22d541111db94909429c89aa
schema:url	https://doi.org/10.1016/j.virol.2008.11.034
resource representing a document's title	West Nile virus genome amplification requires the functional activities of the proteasome
has PubMed Central identifier	PMC7103393
has PubMed identifier	19101004
schema:publication	Virology
resource representing a document's body	covid:a80751d5415f2d5a22d541111db94909429c89aa#body_text
is schema:about of	named entity 'intracellular pathogens' named entity 'proteasome' named entity 'replicons' named entity 'tied' named entity 'proteasome' named entity 'infecting' named entity 'inhibitors' named entity 'PROTEINS' named entity 'WNV' named entity 'CYCLE' named entity 'HOST' named entity 'AMPLIFICATION' named entity 'TESTED' named entity 'TO IDENTIFY' named entity 'RNA VIRUSES' named entity 'INDICATING' named entity 'TO TRANSLATE' named entity 'CASE' named entity 'INTERFERENCE' named entity 'REPLICATE' named entity 'STAGE' named entity 'INTERFERED WITH' named entity 'DEPENDENT' named entity 'ENTRY' named entity 'TIED' named entity 'KNOCK-DOWN' named entity 'PROCESSES' named entity 'DRUGS' named entity 'HOST CELL' named entity 'VIRUSES' named entity 'DID NOT INTERFERE WITH' named entity 'SYNTHETIC' named entity 'EXPRESSION' named entity 'THEIR' named entity '28S' named entity 'LARGE' named entity 'INTRACELLULAR PATHOGENS' named entity 'INFECTING' named entity 'REQUIRED' named entity 'GENES' named entity 'ACTIVITY' named entity 'SILENCING' named entity 'POST' named entity 'HUMAN' named entity 'TREATED' named entity 'INTERFERE' named entity 'REPORT' named entity 'CELLS' named entity 'GENOME' named entity 'HERE' named entity 'REPLICATION' named entity 'WEST NILE VIRUS' named entity 'BLOCKED' named entity 'POSITIVE' named entity 'WNV INFECTION' named entity 'INHIBITORS' named entity 'SPECIFICITY' named entity 'PROTEASOME' named entity 'VENEZUELAN EQUINE ENCEPHALITIS VIRUS' named entity 'INFECTION' named entity 'SUBSET' named entity 'SIRNAS' named entity 'MULTIPLE' covid:arg/a80751d5415f2d5a22d541111db94909429c89aa named entity 'Drugs' named entity 'proteins' named entity 'case' named entity 'synthetic' named entity 'knock-down' named entity 'lifecycle' named entity 'WNV' named entity 'interfere' named entity 'WNV' named entity 'genome' named entity 'host' named entity 'proteasome' named entity 'macromolecular' named entity 'replicate' named entity 'replicons'

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