About: Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host

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About: Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
Creator	Wang, Lin-Fa Shi, Zheng-Li Mani, Shailendra Dutertre, Charles-Antoine Zhang, Qian »more»
source	Medline; PMC
abstract	Bats are special in their ability to host emerging viruses. As the only flying mammal, bats endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether these unique features are interlinked. The important inflammasome sensor, NLR family pyrin domain containing 3 (NLRP3), has been linked to both viral-induced and age-related inflammation. Here, we report significantly dampened activation of the NLRP3 inflammasome in bat primary immune cells compared to human or mouse counterparts. Lower induction of apoptosis-associated speck-like protein containing a CARD (ASC) speck formation and secretion of interleukin-1β in response to both ‘sterile’ stimuli and infection with multiple zoonotic viruses including influenza A virus (−single-stranded (ss) RNA), Melaka virus (PRV3M, double-stranded RNA) and Middle East respiratory syndrome coronavirus (+ssRNA) was observed. Importantly, this reduction of inflammation had no impact on the overall viral loads. We identified dampened transcriptional priming, a novel splice variant and an altered leucine-rich repeat domain of bat NLRP3 as the cause. Our results elucidate an important mechanism through which bats dampen inflammation with implications for longevity and unique viral reservoir status.
has issue date	2019-02-25(xsd:dateTime)
bibo:doi	10.1038/s41564-019-0371-3
bibo:pmid	30804542
has license	no-cc
sha1sum (hex)	a6d837a5c3913691f8887f519dcb5193aed252e0
schema:url	https://doi.org/10.1038/s41564-019-0371-3
resource representing a document's title	Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
has PubMed Central identifier	PMC7096966
has PubMed identifier	30804542
schema:publication	Nat Microbiol
resource representing a document's body	covid:a6d837a5c3913691f8887f519dcb5193aed252e0#body_text
is schema:about of	named entity 'signal 1' named entity 'protein' named entity 'mediated' covid:arg/a6d837a5c3913691f8887f519dcb5193aed252e0 named entity 'IL-1β' »more»

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