About: Newly identified viral genomes in pangolins with fatal disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Newly identified viral genomes in pangolins with fatal disease
Creator	Chen, Shuai Chen, Yan-Mei Zhang, Yong-Zhen Lin, Xian-Dan Holmes, Edward Gao, Wen-Hua Tan, Zhi-Zhou Xie, Chun-Gang Zhou, Jia-Jun
source	Medline; PMC
abstract	Epizootic pathogens pose a major threat to many wildlife species, particularly in the context of rapidly changing environments. Pangolins (order Pholidota) are highly threatened mammals, in large part due to the trade in illegal wildlife. During July to August 2018 four sick wild pangolins (three Manis javanica and one Manis pentadactyla) exhibiting a variety of clinical symptoms were rescued by the Jinhua Wildlife Protection Station in Zhejiang province, China. Although three of these animals died, fortunately one recovered after 2 weeks of symptomatic treatment. Using meta-transcriptomics combined with reverse transcription polymerase chain reaction (RT-PCR), we identified two novel RNA viruses in two of the dead pangolins. Genomic analysis revealed that these viruses were most closely related to pestiviruses and coltiviruses, although still highly genetically distinct, with more than 48 and 25 per cent sequence divergence at the amino acid level, respectively. We named these Dongyang pangolin virus (DYPV) and Lishui pangolin virus (LSPV) based on the sampling site and hosts. Although coltiviruses (LSPV) are known to be transmitted by ticks, we found no evidence of LSPV in ticks sampled close to where the pangolins were collected. In addition, although DYPV was present in nymph ticks (Amblyomma javanense) collected from a diseased pangolin, they were not found in the local tick population. Epidemiological investigation revealed that both novel viruses might have been imported following the illegal international trade of pangolins. Hence, these data indicate that illegal wildlife trafficking not only threatens the status of pangolin populations, but may also spread epizootic pathogens.
has issue date	2020-04-12(xsd:dateTime)
bibo:doi	10.1093/ve/veaa020
bibo:pmid	32296543
has license	cc-by-nc
sha1sum (hex)	a5b52c5ad7be21e6896955d2a98b6fb99c963412
schema:url	https://doi.org/10.1093/ve/veaa020
resource representing a document's title	Newly identified viral genomes in pangolins with fatal disease
has PubMed Central identifier	PMC7151644
has PubMed identifier	32296543
schema:publication	Virus Evol
resource representing a document's body	covid:a5b52c5ad7be21e6896955d2a98b6fb99c963412#body_text
is schema:about of	named entity 'wildlife trafficking' named entity 'addition' named entity 'nymph' named entity 'collected' named entity 'diseased' named entity 'sampling' named entity 'Epizootic' named entity 'RT-PCR' named entity 'ticks' named entity 'symptomatic treatment' named entity 'DATA' named entity 'USING' named entity 'GENOMIC' named entity 'SEQUENCE' named entity 'HAVE' named entity 'NYMPH' named entity 'HOSTS' named entity 'REVEALED' named entity 'SAMPLED' named entity 'population' named entity 'Manis javanica' named entity 'combined' named entity 'weeks' named entity 'ticks' named entity 'close' named entity 'illegal' named entity 'RNA' named entity 'transmitted' named entity 'meta-transcriptomics' named entity 'viruses' named entity 'coltiviruses' named entity 'Epizootic' named entity 'reverse transcription polymerase chain reaction' named entity 'sequence divergence' named entity 'mammals' named entity 'viruses' named entity 'Lishui' named entity 'pangolins' named entity 'Dongyang' named entity 'China' named entity 'Manis javanica' named entity 'Pholidota' named entity 'pangolins' named entity 'fatal disease' named entity 'international trade' named entity '16S rDNA' named entity 'virus isolation' named entity 'du Toit' named entity 'blastn' named entity 'lungs' named entity 'Lishui' named entity 'diarrhea' named entity 'RNA viruses' named entity 'wild boars' named entity 'retrovirus' named entity 'sequence identity' named entity 'coltiviruses' named entity 'Ruian' named entity 'pangolin' named entity 'viruses' named entity 'Lishui' named entity 'China' named entity 'spleen' named entity 'tick' named entity 'Dongyang' named entity 'liver' named entity 'pangolins' named entity 'sendai virus' named entity 'Viral' named entity 'coltiviruses' named entity 'PCR' named entity 'Dongyang' named entity 'coltivirus'

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