About: A SARS-CoV-2 vaccine candidate: In silico cloning and validation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A SARS-CoV-2 vaccine candidate: In silico cloning and validation
Creator	Bhattacharya, Manojit Chakraborty, Chiranjib Ghosh, Pratik Lee, Sang-Soo Patra, Prasanta Sharma, Garima Sharma, Ashish Chiranjibchakraborty, Manojit Bhattacharya, # Patra, Bidhan Patra, Chandra Saha, Rudra
Source	Elsevier; Medline; PMC
abstract	SARS-CoV-2 is spreading globally at a rapid pace. To contain its spread and prevent further fatalities, the development of a vaccine against SARS-CoV-2 is an urgent prerequisite. Thus, in this article, by utilizing the in silico approach, a vaccine candidate for SARS-CoV-2 has been proposed. Moreover, the effectiveness and safety measures of our proposed epitopic vaccine candidate have been evaluated by in silico tools and servers (AllerTOP and AllergenFP servers). We observed that the vaccine candidate has no allergenicity and successfully combined with Toll-like receptor (TLR) protein to elicit an inflammatory immune response. Stable, functional mobility of the vaccine-TLR protein binding interface was confirmed by the Normal Mode Analysis. The in silico cloning model demonstrated the efficacy of the construct vaccine along with the identified epitopes against SARS-CoV-2. Taken together, our proposed in silico vaccine candidate has potent efficacy against COVID-19 infection, and successive research work might validate its effectiveness in in vitro and in vivo models.
has issue date	2020-07-15(xsd:dateTime)
bibo:doi	10.1016/j.imu.2020.100394
bibo:pmid	32835079
has license	no-cc
sha1sum (hex)	a548ef8f642baeb4807cd239b2a7e6828375bb14
schema:url	https://doi.org/10.1016/j.imu.2020.100394
resource representing a document's title	A SARS-CoV-2 vaccine candidate: In silico cloning and validation
has PubMed Central identifier	PMC7361115
has PubMed identifier	32835079
schema:publication	Inform Med Unlocked
resource representing a document's body	covid:a548ef8f642baeb4807cd239b2a7e6828375bb14#body_text
is schema:about of	named entity 'Normal Mode' named entity 'vaccine' named entity 'SARS-COV-2' named entity 'ELICIT' named entity 'ITS' named entity 'CONFIRMED BY' named entity 'SARS-CoV-2' named entity 'allergenicity' named entity 'combined' named entity 'confirmed' named entity 'fatalities' named entity 'model' named entity 'tools' named entity 'inflammatory immune response' named entity 'vaccine' named entity 'epitopic' named entity 'Normal Mode' named entity 'Toll-like receptor' named entity 'vaccine' named entity 'vaccine' named entity 'cloning' named entity 'SARS-CoV-2' named entity 'protein' named entity 'spreading globally' named entity 'vaccine' named entity 'SARS-CoV-2' named entity 'infection' named entity 'epitopes' named entity 'sub-cellular' named entity 'allergenicity' named entity 'electrostatic' named entity 'molecular interactions' named entity 'drug designing' named entity 'immunogens' named entity 'Normal mode' named entity 'cloning' named entity 'prokaryotic' named entity 'vaccine' named entity 'visual molecular dynamics' named entity 'expression vector' named entity 'myalgia' named entity 'Coronavirus' named entity 'vaccine' named entity 'eukaryotic' named entity 'WHO' named entity 'instability index' named entity 'cloning' named entity 'FFT' named entity 'structure-based' named entity 'West Nile virus' named entity 'molecular dynamic simulation' named entity 'cloning' named entity 'force field' named entity 'E. coli' named entity 'epitopes' named entity 'vaccine' named entity 'nucleotides' named entity 'vaccine' named entity 'Fast Fourier Transform' named entity 'TLR4' named entity 'protein-protein docking' named entity 'expression vector' named entity 'vaccine' named entity 'epitopes' named entity 'fatigue' named entity 'TLR5' named entity 'chimeric vaccine' named entity 'E. coli' named entity 'vaccine' named entity 'TLR4'

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