About: The Infectious Nature of Patient-Generated SARS-CoV-2 Aerosol

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Infectious Nature of Patient-Generated SARS-CoV-2 Aerosol
Creator	Fang, Ying Brett-Major, David Lowe, John Lawler, James Reid, St Herrera, Vicki Rivera, Danielle Santarpia, Joshua Callahan, Michael Conoan, Nicholas Denton, Paul Martens, Jacob Ratnesar-Shumate, Shanna
Source	MedRxiv
abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission causing coronavirus disease 2019 (COVID-19) may occur through multiple routes. We collected aerosol samples around six patients admitted into mixed acuity wards in April of 2020 to identify the risk of airborne SARS-CoV-2. Measurements were made to characterize the size distribution of aerosol particles, and size-fractionated, aerosol samples were collected to assess the presence of infectious virus in particles sizes of >4.1 m, 1-4 m, and <1 m in the patient environment. Samples were analyzed by real-time reverse-transcriptase polymerase chain reaction (rRT-PCR), cell culture, western blot, and transmission electron microscopy (TEM). SARS-CoV-2 RNA was detected in all six rooms in all particle size fractions (>4.1 m, 1-4 m, and <1 m). Increases in viral RNA during cell culture of the virus from recovered aerosol samples demonstrated the presence of infectious, replicating virions in three <1 m aerosol samples (P<0.05). Viral replication of aerosol was also observed in the 1-4 m stage but did not reach statistical significance (0.05<P<0.10). Western blot and TEM analysis of these samples also showed evidence of viral proteins and intact virions. The infectious nature of aerosol collected in this study further suggests that airborne transmission of COVID-19 is possible, and that aerosol prevention measures are necessary to effectively stem the spread of SARS-CoV-2.
has issue date	2020-07-20(xsd:dateTime)
bibo:doi	10.1101/2020.07.13.20041632
has license	medrxiv
sha1sum (hex)	a50c3ec1c21bb890241799c25ac22ba8df11101b
schema:url	https://doi.org/10.1101/2020.07.13.20041632
resource representing a document's title	The Infectious Nature of Patient-Generated SARS-CoV-2 Aerosol
resource representing a document's body	covid:a50c3ec1c21bb890241799c25ac22ba8df11101b#body_text
is schema:about of	named entity 'routes' named entity 'prevention' named entity 'assess' named entity 'patients' named entity 'risk' named entity 'Measurements' named entity 'Aerosol' named entity 'OBSERVED' named entity 'PREVENTION MEASURES' named entity '10%' named entity '2C CELL' named entity 'collected' named entity 'transmission' named entity 'collected' named entity 'aerosol' named entity 'recovered' named entity 'sizes' named entity 'virus' named entity 'Samples' named entity 'aerosol' named entity 'coronavirus disease 2019' named entity 'proteins' named entity 'distribution' named entity 'aerosol' named entity 'samples' named entity 'measures' named entity 'collected' named entity 'Nature' named entity 'aerosol particles' named entity 'airborne transmission' named entity 'Severe acute respiratory syndrome coronavirus 2' named entity 'aerosol' named entity 'aerosol' named entity 'Western blot' named entity 'RNA' named entity 'statistical significance' named entity 'cell culture' named entity 'aerosol' named entity 'reverse-transcriptase' named entity 'COVID' named entity 'coronavirus disease 2019' named entity 'SARS-CoV-2' named entity 'aerosol' named entity 'rRT-PCR' named entity '1 µm' named entity 'SARS-CoV-2' named entity 'western blot' named entity 'aerosol' named entity 'virions' named entity 'SARS-CoV-2' named entity 'aerosol' named entity 'aerosol' named entity 'aerosol' named entity 'virus' named entity 'rRT-PCR' named entity 'glyceraldehyde 3-phosphate dehydrogenase' named entity 'supernatant' named entity 'protein' named entity 'viral replication' named entity 'standard curve' named entity 'aerosol' named entity 'cross-contamination' named entity 'aerosol' named entity 'Invitrogen' named entity 'geometric standard deviation' named entity 'viral RNA' named entity 'nuclease' named entity 'gelatin' named entity 'statistically significant' named entity 'larynx' named entity 'RNA' named entity 'rRT-PCR' named entity 'SARS-CoV-2'

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