About: Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study
Creator	Yang, Jian Li, Hui Chen, Lan Xiao, Yan Cao, Bin Xiong, Yan Hu, Yi Guo, Li Wu, Chao Qin, Chuan Jin, Qi Liu, Bo Gao, Hong Dong, Jie Yang, Fan Li, Li Cheng, Zhen-Shun Zhao, Jian-Ping Wang, Jian-Wei Xu, Teng Huang, Chao-Lin Liu, Lin-Lin Dan, Dong Dongcheng, Fan, Guo-Hui Gu, Xiao-Ying Hao, Xiu-Yuan Jiang, Yong-Zhong Jie, Dong Jing, Rong Li, Li, Xing-Wang Li, Yong-Jun Liu, Yi-Wei Pan, Jia Qian, Zhao-Hui Ren, Li-Li Tiao, San Wang, Xiao-Rui Wang, Xin-Ming Wang, Ye-Ming Wei, Pei-Fang Wu, Zhi-Qiang Xiang, Zi-Chun Xu, Jiu-Yang Yuan, Nan
topic	covid:a4f38656b672b4a4821a5d12ebfe78dc51fc2ba0#this
Source	Medline; PMC
abstract	BACKGROUND: Human infections with zoonotic coronaviruses (CoVs), including severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV, have raised great public health concern globally. Here, we report a novel bat-origin CoV causing severe and fatal pneumonia in humans. METHODS: We collected clinical data and bronchoalveolar lavage (BAL) specimens from five patients with severe pneumonia from Jin Yin-tan Hospital of Wuhan, Hubei province, China. Nucleic acids of the BAL were extracted and subjected to next-generation sequencing. Virus isolation was carried out, and maximum-likelihood phylogenetic trees were constructed. RESULTS: Five patients hospitalized from December 18 to December 29, 2019 presented with fever, cough, and dyspnea accompanied by complications of acute respiratory distress syndrome. Chest radiography revealed diffuse opacities and consolidation. One of these patients died. Sequence results revealed the presence of a previously unknown β-CoV strain in all five patients, with 99.8% to 99.9% nucleotide identities among the isolates. These isolates showed 79.0% nucleotide identity with the sequence of SARS-CoV (GenBank NC_004718) and 51.8% identity with the sequence of MERS-CoV (GenBank NC_019843). The virus is phylogenetically closest to a bat SARS-like CoV (SL-ZC45, GenBank MG772933) with 87.6% to 87.7% nucleotide identity, but is in a separate clade. Moreover, these viruses have a single intact open reading frame gene 8, as a further indicator of bat-origin CoVs. However, the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor. CONCLUSION: A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans.
has issue date	2020-02-11(xsd:dateTime)
bibo:doi	10.1097/cm9.0000000000000722
bibo:pmid	32004165
has license	no-cc
sha1sum (hex)	a4f38656b672b4a4821a5d12ebfe78dc51fc2ba0
schema:url	https://doi.org/10.1097/cm9.0000000000000722
resource representing a document's title	Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study
has PubMed Central identifier	PMC7147275
has PubMed identifier	32004165
schema:publication	Chin Med J (Engl)
resource representing a document's body	covid:a4f38656b672b4a4821a5d12ebfe78dc51fc2ba0#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/a4f38656b672b4a4821a5d12ebfe78dc51fc2ba0
is schema:about of	named entity 'isolates' named entity 'bronchoalveolar lavage' named entity 'sequence' named entity 'acute respiratory distress syndrome' named entity 'Middle East respiratory syndrome' named entity 'humans' named entity 'patients' named entity 'viruses' named entity 'public health' named entity 'accompanied' named entity 'carried' named entity 'MAXIMUM' named entity 'YIN' named entity 'IDENTITIES' named entity 'MIDDLE EAST RESPIRATORY SYNDROME ' named entity 'NEXT-GENERATION SEQUENCING' named entity 'SINGLE' named entity 'UNKNOWN' named entity 'AMINO ACID SEQUENCE' named entity 'CONSOLIDATION' named entity 'CLADE' named entity 'BUT' named entity 'LIKE' named entity 'SARS' named entity 'NUCLEIC ACIDS' named entity 'TREES' named entity 'CLOSEST' named entity 'IDENTIFIED' named entity 'PUBLIC HEALTH' named entity 'GENE' named entity 'Sequence' named entity 'intact' named entity 'SARS-CoV' named entity 'severe'

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